Natural Honey- as an Effective Adjunct in the Management of Radiation Induced Oral Mucositis
Keywords:Apitherapy, Honey, Normal saline, Radiation induced mucositis, Radiotherapy.
Background - Malignancies are second most common cause of death in the world. Betel quid chewing,
smoking, alcohol and low socioeconomic status contribute to its high prevalence. Its treatment protocol
includes surgery, radiotherapy, chemotherapy or a combination. Oral mucositis is an unavoidable most
frequent, painful, distressing clinical side effect of radiotherapy.
Methods – The study group consisted of 102 subjects diagnosed with carcinoma of head and neck and
planned for radiotherapy and had developed oral mucositis, among which 51 were in control group and 51
in interventional group. The control group received 0.9% normal saline while interventional group received
natural honey as topical application. Both the groups were evaluated by World Health Organization oral
mucositis assessment scale and symptoms were assessed on verbal basis at baseline (I visit) and along with
four follow-up visits at an interval of 10 days, for total period of 40 days by 2 investigators. The study
duration was of 2 years.
Conclusion- This study concludes that the topical application of honey can be used as an adjunct in
alleviating the symptoms and in effective management of radiation mucositis as it is an easily available,
simple, potent and inexpensive agent.
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