Bio Functional Evaluation of EGFR Expression as a Prognostic Indicator in Oral Squamous Cell Carcinoma and a Recommendation for Personalized Targeted Therapy with Anti EGFR Inhibitors
Keywords:Epidermal Growth Factor Receptor (EGFR), EGFR inhibitors Immunohistochemistry, Squamous Cell Carcinoma.
Background: Carcinoma is a complex, multifactorial and a devastating disease. Understanding the molecular
changes that leads to disease enables one to develop strategies to prevent, provide an early diagnosis and
serve as targets for therapy. Epidermal Growth Factor Receptor (EGFR), a 170-kDa cell-surface protein
is a tyrosine kinase receptor from the ErbB family and is involved in many biological processes that
affect tumour development, growth progression, differentiation, inhibition of apoptosis and development
of metastasis. Methods: Study included 54 cases of oral squamous cell carcinomas. EGFR expression by
immunohistochemistry has been studied, correlated with clinical parameters, known prognostic factors and
patient survival to note its significance.
Conclusion: Head and Neck Squamous Cell Carcinoma (HNSCC) with or without regional lymph node
metastases, are challenging to treat effectively. The prognosis for the patients with advanced stage of the
disease still remains poor. The correlation of EGFR overexpression with tumour size, grade, stage and
survival suggests that EGFR expression can be considered as having prognostic significance and is a
potential target for therapy with EGFR inhibitors in HNSCC. Further studies are required to assure the
viability of EGFR levels in saliva as non-invasive prognostic marker and also as an indicator of recurrence.
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