Comparison of Casein Phosphopeptide Amorphous Calcium Phosphate Fluoride and Fluoride Varnish on Remineralization of Early Caries Lesions Around Orthodontic Brackets
Keywords:Tooth remineralization , Amorphous calcium phosphate, Fluorides, orthodontics
Objectives: Orthodontic treatment increases the risk of caries and enamel white spot lesions incidence on
the buccal surface of teeth. This study aims to compare the effect of Casein PhosphoPeptide Amorphous
Calcium Phosphate Fluoride and fluoride varnish on remineralization of white spot lesions around orthodontic
Materials and Methods: In this in-vitro study, 60 premolars teeth were etched for 15 seconds. Then brackets
were bonded with Relicane bond. All teeth were immersed in a demineralization solution for 4 days.
The lower part of the bracket was painted with nail polish to prevent the effect of a remineralizing agent
to serve as a control group. The teeth were divided into 4 groups, Group 1: treated with fluoride varnish for
3 weeks (one-time application), Group2: treated with fluoride varnish for 6 weeks (two-time application),
Group 3: treated with casein phosphopeptide and amorphous calcium phosphate with fluoride (CPP-ACPF)
for 3 weeks (twice a day), Group 4: treated with CPP-ACPF for 6 weeks (twice a day). Remineralizing agent
was applied on the occlusal of bracket for every tooth Area.
then the depth of specimens in treatment and control groups was measured by AutoCAD 2007. Pair-T test
and repeated measured ANOVA were used for data analysis by SPSS 23.
Result: There was no statistically significant difference between each group of treatment. However, mean
remineralization depth in group fourth and mean remineralization area in group three were higher than other
Conclusion: Fluoride varnish and CPP-ACPF have the potential to treat the white spot lesion which is
created during orthodontic treatment. According to less fluoride varnish use, it seems this substance is a
better option in case of patient’s cooperation is not good.
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