Role of PRGF (Plasma Rich in Growth Factors) in Periodontal Regeneration
Keywords:Healing, leucocytes, periodontal regeneration, plasma rich in growth factors
Platelet-rich-growth-factors (PRGF), a modification of fibrin glue made from autologous blood, is being
used to deliver growth factors in high concentration to sites requiring osseous grafting. Growth factors
released from the platelets include platelet-derived growth factor(PDGF), transforming growth factor-beta
(TGF-ß), platelet-derived epidermal growth factor (PDGF), platelet-derived angiogenesis factor, insulin-like
growth factor 1(IGF1), and platelet factor 4. These factors signal the local mesenchymal and epithelial cells
to migrate, divide, and increase collagen and matrix synthesis. Anitua et al in 2001 introduced the concept of
PRGF and since then it has been used for a variety of purposes in the field of dentistry and oral implantology
for proper wound healing and regeneration of periodontal tissues. This review aims to give a brief idea
about the various uses of PRGF and the possibility of utilization in the future taking into consideration many
studies that have been done. The main advantage of using PRGF is that it lacks the leukocyte content thus
preventing damage to the tissues during healing due to the acid hydrolases and proteases released from the
neutrophils. It has been previously used for treating intrabony defects, to increase the implant-bone contact
area, for recession coverage etc. In other fields of medicine, it has been used to cure osteoarthritis, to treat
chronic ulcers as well. Therefore, PRGF is a very effective blood concentrate with a high concentration of
growth factors and its use should be increased in the clinical practice.
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