Platelet Rich Fibrin( PRF )-A Novel Generation of Regeneration in Endodontics: A Review


  • Manali Nath
  • Shashirekha Govind
  • Siba Prasad Jena



Regenerative endodontics, PRF, Platelet concentrates, Tissue engineering


In the field of regenerative medicine, PRP/PRF whichwas will be is used as a surgical adjuvant became
the new glorified approach. For the Regenerative endodontic treatment based on the tissue engineering
concept, creating a favourable environment free of pathogens, for preservation and migration of stem cells,
pathogen eradication, stem cell preservation, presence of scaffold facilitating spatial orientation and signal
molecules released by cells is of utmost importance. In tooth revascularisation and revitalization, successful
application of platelet concentrates as scaffolds have been reported. Being autologous, comprising of high
growth factor concentrates and relatively hassle-free preparation in dental setup, platelet concentrates are
preferred. The advancement in the regenerative endodontics field, with the introduction of the different
generation of platelet concentrates, is a breakthrough.

Author Biographies

Manali Nath

Post Graduate Trainee

Shashirekha Govind

Professor & Head

Siba Prasad Jena

Senior Lecturer, Department of Conservative Dentistry and
Endodontics, Institute of Dental Science, Siksha O Anusandhan (Deemed to be University) Bhubaneswar



How to Cite

Manali Nath, Shashirekha Govind, & Siba Prasad Jena. (2021). Platelet Rich Fibrin( PRF )-A Novel Generation of Regeneration in Endodontics: A Review. Indian Journal of Forensic Medicine & Toxicology, 15(2), 3938-3943.

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