Probiotics Intake as Adjunct Therapy for Infected Health-Care with SARS COV-2


  • Anna Surgean Veterini
  • Eighty Mardiyan Kurniawati
  • Hamzah
  • Subijanto Marto Soedarmo
  • Cita Rosita Sigit Prakoeswa
  • Damayanti Tinduh



Probiotics; Immunomodulator; COVID-19


Objectives: We performed this case-control observational study to evaluate the comparison of the length of
duration of SARS COV-2 infection and the cycle threshold (Ct) value of reverse-transcriptase polymerase
chain reaction (RT-PCR) nasopharynx swab between the probiotics intake (case) group and the nonprobiotics intake (control) group.
Materials and Methods: Our study was a case-control study involving 15 cases and 15 controls match
for RT-PCR positive results. The participants were healthcare consisted of registrars, consultants, and
nurses. Each participant was interviewed by google forms using a structured questionnaire to collect sociodemographic characteristics, diet, therapy from a pulmonologist, and adjunct therapy.
Results: The total participants consisted of 15 males and 15 females. 4 participants in the case group had
febrile, 1 participant with anosmia, 1 participant with febrile, nausea, and vomit before they consumed
probiotics, and 9 participants without clinical complaints. One participant in the control group had fevered
and cough, 14 participants without clinical complaints—1 participant with co-morbidities in the control
group. The data of age, duration of infection, and cycle threshold (Ct) value were in the normal distribution.
Analysis results using SPSS 21.00 show no significant differences in the course of disease between the case
group and the control group. We found 2 participants in the control group had re-infection, while there was
no re-infection in the case group.
Conclusion: The present study’s finding may imply future care for the viral infection through the
immunomodulation mechanism by probiotics consumption.

Author Biographies

Anna Surgean Veterini

Anesthesiologist Intensivist

Eighty Mardiyan Kurniawati



Anesthesiologist Intensivist

Subijanto Marto Soedarmo

Prof., Pediatrician

Cita Rosita Sigit Prakoeswa

Prof. Dermatologist

Damayanti Tinduh

Medical Rehabilition Specialist of Dr Soetomo General Academic Hospital – Universitas
Airlangga, Address: Jalan Prof. Dr. Moestopo 6-8 Surabaya, Indonesia



How to Cite

Anna Surgean Veterini, Eighty Mardiyan Kurniawati, Hamzah, Subijanto Marto Soedarmo, Cita Rosita Sigit Prakoeswa, & Damayanti Tinduh. (2021). Probiotics Intake as Adjunct Therapy for Infected Health-Care with SARS COV-2. Indian Journal of Forensic Medicine & Toxicology, 15(2), 4021-4025.

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