Toxicity of Cadmium Chloride on White Rats Liver and the Protective Role of Brassica Nigra Seed Extract
Keywords:cadmium chloride, Brassica nigra, aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP).
The study designed for the toxic role of cadmium chloride on the liver of mice from both a physiological
and histological aspects. The animals were treated with a dose of 5 mg/kg of body weight for 30 days. And
the protective role of Brassica nigra seed extract against cadmium chloride toxicity. This pilot study was
conducted on 20 adult white rats divided into 4 equivalent groups including the control group: Animals in
this group received a dosed of distilled water for 30 days. The placebo group was treated with cadmium
chloride at a dose of 5 mg/kg of body weight for 30 days and returned as an infected control group. While
in the third group, animals treated with cadmium chloride were dosed with Brassica nigra seed extract
at a dose of 200 mg/kg of body weight for 30 days. The fourth group was dosed with Brassica nigra
seed extract at a dose of 200 mg/kg of body weight for 30 days. After 30 days, liver enzymes including
aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were measured
by spectrophotometric method. In addition to making tissue sections of the liver. The treatment of rats
led to a significant increase (P?0.05) in liver enzymes compared with the control group. It also led to
histopathology in the liver tissue, while the Brassica nigra seed extract acted as a protective role against the
toxicity of cadmium chloride.
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