Study the Negative Effects of Pseudoephedrine on Brain Tissues in Adult Albino Male Rats

Authors

  • Raghad Hazem Hamad Al-Abbasi
  • Muneef Saab Ahmad Al-Janabi
  • Iyad Hamid Ibrahim

DOI:

https://doi.org/10.37506/ijfmt.v15i2.15044

Keywords:

nervous system, pseudoephedrine, brain tissue, male rats.

Abstract

In this study, (24) male animals were used, which were divided randomly into four groups. Each group
included (6) animals, which are: the control group that was given drinking water and food daily, and the
group of rats treated with pseudoephedrine at a dose of (40) mg / Kg of body weight for a period of (30)
days, the group of rats treated with pseudoephedrine at a dose of (40) mg / kg of body weight for a period
of (40) days, the group of rats treated with pseudoephedrine at a dose of (40) mg / kg of body weight for a
period of (50) days, the animals dosed the drug by the oropharyngeal tube at a dose of (1) ml, and after the
end of the experiment, the animals were scarified , brain samples were taken and preserved with formalin
at a concentration of 10% until the tissue sections were made, when the meningeal membrane appeared the
upper layers of the cerebral cortex in the group treated with pseudoephedrine for a period of 30 days were
close to normal, while the group treated with pseudoephedrine for a period of (40) days showed shrinkage
in the deep layers of the cerebral cortex and hemolysis in many blood vessels, and the meningeal membrane
appeared.

Author Biographies

Raghad Hazem Hamad Al-Abbasi

Lec. Pathological Analysis Department / College of Applied Sciences / Samarra University

Muneef Saab Ahmad Al-Janabi

Prof. Department of
Life Sciences / College of Education for Pure Sciences / University of Tikrit

Iyad Hamid Ibrahim

Prof. College of Veterinary Medicine
/ University of Tikrit

Published

2021-03-24

How to Cite

Raghad Hazem Hamad Al-Abbasi, Muneef Saab Ahmad Al-Janabi, & Iyad Hamid Ibrahim. (2021). Study the Negative Effects of Pseudoephedrine on Brain Tissues in Adult Albino Male Rats. Indian Journal of Forensic Medicine & Toxicology, 15(2), 4289-4295. https://doi.org/10.37506/ijfmt.v15i2.15044