Argyrophilic Nucleolar Organizer Regions in Premalignant and Malignant Oral Lesion: A Quantitative and Qualitative Assessment

Authors

  • Shafali Singh
  • Seema Sharma
  • Manu Gupta
  • Akansha Singh

DOI:

https://doi.org/10.37506/ijfmt.v15i2.15048

Keywords:

Argyrophilic nucleolar organizer regions, epithelial dysplasia, oral squamous cell carcinoma.

Abstract

Background: Argyrophilic nucleolar organizer regions (AgNORs) has been considered to be useful in
diagnostic pathology, mainly to distinguish benign lesions from their malignant counterparts.
Aim: This study was done to evaluate the significance of various AgNOR parameters in differentiating
premalignant and malignant oral lesions.
Materials and Methods: The study was performed on thirty five archival tissues consisting of sample
comprised of five normal mucosa, fifteen premalignant lesions and fifteen malignant oral lesions. AgNORs
were assessed both quantitatively and qualitatively. The data were analyzed using ANOVA and Chi square
test.
Results: Quantitatively and qualitatively significant difference was noticed. Quantitatively significant
difference in the mean value of AgNORs noticed between the premalignant and malignant lesions. In terms
of qualitatively, the premalignant and malignant oral lesions differed significantly from normal mucosa.
Conclusion: To conclude, the AgNOR count is the most appropriate marker to differentiate between
premalignant and malignant oral lesions.

Author Biographies

Shafali Singh

Senior Lecturer, Department of Oral Pathology & Microbiology, School of Dental Sciences, Sharda University,
Greater Noida

Seema Sharma

Professor & Head of Department, Department of Oral Pathology & Microbiology, Santosh Dental
College, Ghaziabad

Manu Gupta

Reader, Department of Oral Pathology & Microbiology, Santosh Dental College,
Ghaziabad

Akansha Singh

Consultant Physiotherapist at Private Clinic

Published

2021-03-24

How to Cite

Shafali Singh, Seema Sharma, Manu Gupta, & Akansha Singh. (2021). Argyrophilic Nucleolar Organizer Regions in Premalignant and Malignant Oral Lesion: A Quantitative and Qualitative Assessment. Indian Journal of Forensic Medicine & Toxicology, 15(2), 4318-4362. https://doi.org/10.37506/ijfmt.v15i2.15048