Role of Serum Malondialdehyde (MDA) and Vitmin- C Level in Non-Smokers and Chronic Smokers with Acute Myocardial Infarction (AMI) in Male
Keywords:Chronic smokers, Myocardial infarction, MDA, Vitamin C
Introduction: Cigarette smoking is recognized as a serious health hazard as each cigarette tears away 7-11
minutes of human life. The present study aimed to investigate the serum MDA and vitamin c levels in nonsmoker and chronic smoker with AMI patient and its association with cigarette consumption. Cigarette
smoke contains many oxidants capable of generating reactive oxygen species and reactive nitrogen species.
These species play a key role in oxidative stress, leading to the development and progression of many
disorders, including hypertension, cancer, diabetes mellitus and cardiovascular diseases.
Methods: This study was conducted in the Medicine Department at DMMC & SMHRC, Nagpur in
collaboration with ABVRH, Sawangi (Meghe) during September 2020 to January 2021. Informed consent
was obtained from all the subjects. 40 controls who were apparently healthy non-smokers were included
after appropriate matching (for age and sex) and 40 apparently healthy chronic smokers were selected 40
chronic smokers with diagnosed acute myocardial infarction were selected from SMHRC. All of them were
Result: The MDA and vitamin C were compared between Group A and Group B and also between Group B
and Group C. There was a significant rise in MDA (p<0.0001) and significant decrease in vitamin C (p<0.01)
in Group B compared to Group A. There was a significant rise in MDA (p<0.0001) and significant decrease
in vitamin C (p<0.001) in Group C compared to Group B.
Conclusions: The increase in serum MDA level and decrease in vitamin C was found in chronic smokers
compared to non-smokers. It was also found that there is increase in serum MDA and decrease in vitamin C
in smokers with AMI compared with smokers without AMI, and the reason for this inter-subject variability
of MDA and vitamin C levels may be due to gene-environmental factors.
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