Genetic Polymorphisms of the Efflux Transporter Gene ABCB1 and Their Effects on the Anastrozole Response in Iraqi Breast Cancer Patients

Authors

  • Hiba Salah Mahdi
  • Ahmed Salih Sahib
  • Hassan Mahmood Mousa Abo Almaali
  • Karrar Kadhim Mohsin

DOI:

https://doi.org/10.37506/ijfmt.v15i2.15059

Keywords:

Anastrozole, ABCB1 gene, estradiol, cancer antigen CA15.3, arthralgia.

Abstract

Background: The ABCB1 gene (ATP-binding cassette) encodes the ABCB1 transporter. Anastrozole is a
substrate for the ABCB1 efflux transporter. The objective of the study was to detect the genetic polymorphisms
of this efflux transporter in Iraqi breast cancer patients and their effects on the anastrozole response.
Method: Blood samples were taken from breast cancer patients, and a portion of each sample was used for
biochemical analysis (measuring estradiol and cancer antigen 15.3 levels), while the remaining portion was
used for genetic analysis. Genotyping demonstrates that the mutant genotype being the most frequent type
for both C1236T and C3435T SNPs.
Results: The result indicated nonsignificant differences in the serum levels of estradiol or cancer antigen
15.3 among different genotype groups of the ABCB1 gene.
Conclusion: It is concluded that the ABCB1 gene is highly polymorphic in Iraqi women with breast cancer.
This study indicated that ABCB1 gene may not affect the response to anastrozole.

Author Biographies

Hiba Salah Mahdi

Bachelor in Pharmacy, Department of Pharmacology and Toxicology, College of Pharmacy, University of
Kerbala, Iraq

Ahmed Salih Sahib

Professor, Department of Pharmacology and Toxicology, College of Pharmacy, University of
Kerbala, Iraq

Hassan Mahmood Mousa Abo Almaali

Assistant Professor, Department of Clinical Laboratory Sciences, College of Pharmacy, University
of Kerbala, Iraq

Karrar Kadhim Mohsin

Diploma, Imam Al-Hussein Hematology and Oncology Center, The Holy City of Kerbala, Iraq

Published

2021-03-24

How to Cite

Hiba Salah Mahdi, Ahmed Salih Sahib, Hassan Mahmood Mousa Abo Almaali, & Karrar Kadhim Mohsin. (2021). Genetic Polymorphisms of the Efflux Transporter Gene ABCB1 and Their Effects on the Anastrozole Response in Iraqi Breast Cancer Patients. Indian Journal of Forensic Medicine & Toxicology, 15(2), 4401-4408. https://doi.org/10.37506/ijfmt.v15i2.15059