Clinical important of E-Cadherin, CA15-3 and CEA in Diagnostic and Flow Up for Breast Cancer Patients

Authors

  • Alaa Haleem Imran
  • Sahib Ali Al-atrachji
  • Karar Kadhim Al-mosawi

DOI:

https://doi.org/10.37506/ijfmt.v15i2.15060

Keywords:

CA15-3, CEA, E-cadherin, MUC-1, CEA

Abstract

Background: The normal prevailing cancer in the women is Breast cancer, other than nonmelanoma skin
cancer. E-cadherin performs an essential role in epithelial cell adhesion and the decline of its role is the main
donor to cancer rise because the majority of solid tumors are carcinomas that occur from epithelial tissue. A
segment of the mucin-1 (MUC-1) is the cancer antigen 15-3 (CA15-3) order of glycoproteins, is classified
as a serviceable tumor marker inspired by revised glycosylation of itself. The carcinoembryonic antigen
(CEA) levels is raise in the blood, as a sort of cell adhesion molecule are associated with tumor metastasis.
Methods A cross-sectional study held implemented on100 specimens, 50 patient with breast cancer ere and
subsequent chemotherapy therapy with 50 healthy individuals (healthy patients).
Results The result reveals significant disparities patient group the same patient as a novel cause, following
initial chemotherapy procedure and matched with the control group in some tumors markers such as (CA15-
3, CEA) exact (E-cadherin) shows non-significant.
Conclusions Our cross-sectional study designates that the E-Cadherin was non-significant for breast cancer
patients including Tumors markers (CA15-3, CEA) bestows significance with breast cancer patients.

Author Biographies

Alaa Haleem Imran

Assistant Lecturer, Department of Biochemistry, College of Medicine, University of Kerbala / Kerbala – Iraq

Sahib Ali Al-atrachji

Professor, Department of Biochemistry, College of Nursing, University of Kerbala / Kerbala – Iraq

Karar Kadhim Al-mosawi

Lecturer,
Consultant Supervisor, Oncology Department, Al-Hussain Medical City– Iraq

Published

2021-03-24

How to Cite

Alaa Haleem Imran, Sahib Ali Al-atrachji, & Karar Kadhim Al-mosawi. (2021). Clinical important of E-Cadherin, CA15-3 and CEA in Diagnostic and Flow Up for Breast Cancer Patients. Indian Journal of Forensic Medicine & Toxicology, 15(2), 4409-4414. https://doi.org/10.37506/ijfmt.v15i2.15060