The Influence of Fluoxetine Therapy Combination of Rational Emotive Behaviour Therapy Againts the Improvement of Depression Symptoms, Cognition Function and Improvement of Brain-Derived Neurotrophic Factors Serum Levels in Patients with Depressive

Abstract

Introduction: Depression is a health problem in the world that has affected more than 300 million people
around the globe. This health problem is characterized by feeling sad, depressed, irritability as well as
distortion of cognition such as self-criticism, feeling of guilt, feeling of worthlessness, lower self-confidence,
pessimism and hopelessness where their manifestations may vary for each individual. Method: In this study,
it compares the fluoxetine group combination of Rational Emotive Behavior Therapy (REBT) with the
fluoxetine group in the treatment of reducing symptoms of depression and improving cognitive function.
This research is an experimental research with pre-test and post-test control group design. The sampling
technique was done by using consecutive sampling for each group. Results: From the results of the study
it was found that the mean of Hamilton Depression Rating Scale (HDRS), the Indonesian version of the
Montreal Cognitive Assessment (MoCA-Ina) and Brain-Derived Neurotrophic Factor (BDNF) serum levels
in the samples given by both groups experienced statistically improvements. Conclusion: there is an effect
on the provision of fluoxetine therapy combination of REBT compared to fluoxetine therapy alone in
improving depressive symptoms, cognitive function as well as increasing BDNF serum levels.