An Observational Study of Propofol Mct-Lct Versus Propofol Lct with Lidocaine Pretreatment for Pain During Induction in General Anaesthesia
Keywords:MCT-LCT Propofol, LCT Propofol, Pain, Lidocaine pretreatment, Venous occlusion, General anesthesia.
Aims and Objectives: To compare efficacy between Propofol Medium Chain Triglycerides-Long Chain
Triglycerides and Propofol Long Chain Triglycerides with lidocaine pretreatment under venous occlusion
on propofol induced pain.
Material and Methods: 50 patients of age 18 to 55 years of either gender of ASA I or II Grade were assigned
to two groups of 25 each undergoing elective surgeries under general anaesthesia.Patients in Group M
received Propofol MCT-LCT 1% (without any pretreatment with Lidocaine) and Group L received Propofol
LCT 1% with Lidocaine pretreatment under venous occlusion. Following propofol injection, patients were
asked for any sensation of pain at injection site during propofol injection till patient was unconscious. It was
graded as per 4 point verbal pain score, with 0 being No pain to 3 being severe pain.
Anaesthesia was induced by a standard technique of intravenous induction. Endotracheal intubation was
done after giving injection succinyl choline (2mg/kg) I V and was maintained on O2, N2O, Isoflurane
and Atracurium. Monitoring of heartrate, blood pressure and SPO2 were done during the surgery . After
surgery, reversal of neuromuscular blockade was done and extubation was performed. After that patient was
transferred to recovery room.
Result and Summary: Both the groups were comparable in term of demographics and ASA grading. It was
observed that in the group L a significantly higher proportion (80%) of patients experienced pain while in
the Group M only 44% patients experienced pain during propofol administration. (P value-0.0044- highly
significant). We observed that the pain intensity score seen in group L was 0, 1, 2 and 3 in 20%, 48%, 20%
and 12% of the patients , while in the group M was 0 and 1 in 56% and 44% of the patients, respectively and
none of the patients had pain score of 2 and 3. A significantly higher proportion of patients in group M had
pain intensity score of 0 (P value<0.01)which was statistically highly significant. Pre and post-operative
vitals were comparable in both the groups.
Conclusion: The study concluded that Propofol MCT-LCT is better in view of less incidence and severity
of pain on injection during induction of anaesthesia than Propofol LCT with lidocaine pretreatment under
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