An Observational Study of Intravenous Granisetron Vs Oral Gabapentin in Preventing Postoperative Nausea and Vomiting after Middle Ear Surgery
Keywords:PONV, Granisetron, Gabapentin, Middle ear surgery.
Background- Postoperative nausea and vomiting (PONV) is one of the most unpleasant complications after
middle ear surgery. Several studies have demonstrated use of gabapentin as antiemetic. This study aims at
comparison of intravenous granisetron vs oral gabapentin in preventing PONV.
Methods - 64 patients of ASA I or II between the ages of 18 and 65 years were divided equally into two
groups. Patients in group I received 3mg granisetron iv 2 minutes and patients in group II received 300
mg gabapentin orally 1 hour prior to surgery. Patients were premedicated with inj. glycopyrrolate and inj.
midazolam. Anaesthesia was induced, maintained and reversed in usual manner. Haemodynamic changes
and number of episodes of nausea and vomiting were recorded upto 24 hours postoperatively. No statistically
significant difference was observed in both the groups at 0 and 1 hour in preventing PONV (p<0.05). Next 24
hours postoperatively neither group showed PONV. No significant haemodynamic changes were observed
and there were noside effects in either of the groups.
Conclusion- There was no statistically significant difference in prevention of PONV in the patients who had
either received inj granisetron 3mg i.v. 2 minutes prior to surgery or oral Gabapentin 300mg 1hour prior to
surgery after middle ear surgery without any side effects.
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