Imprints of miRNA- An Update
Keywords:miRNA, MicroRNA, Profiling, Biomarker, Oral cancer
Introduction: Micro Ribonucleic acid (miRNA) is the novel fraction of non-coding RNA, which
is considered as the biological measure of genetic state of a cell. It plays a mantle regulatory role post
transcriptionally, involving both biological and pathologic cellular processes. miRNAs possess unique
properties like, abundant tissue expression which allows for reproducible isolation and quantification.
Methods: Literature search was carried out by using different combinations of keywords on Pub Med and
Cochrane database to retrieve the data for the literature review.
Discussion: Distinct expression profiles of miRNA in OSCC (Oral Squamous Cell Carcinoma) offers the
use of specific miRNAs signature for early-stage diagnosis, prediction and prognosis. It plays a critical role
in the initiation and progression of cancer functioning either as an oncogene or as tumor suppressor. At
present, it has a huge impact on understanding the aberrant gene modifications in OSCC and its future effects
on prognosis and therapeutic relevance needs to be looked upon.
Conclusion: Distinct phases of miRNA from its origin, properties, functionality, detection, cancer association
to future trends are updated in this review.
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