Imprints of miRNA- An Update

Authors

  • Priya N S
  • Ramakant Nayak
  • Vijayalakshmi K
  • Kishore Bhat

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15335

Keywords:

miRNA, MicroRNA, Profiling, Biomarker, Oral cancer

Abstract

Introduction: Micro Ribonucleic acid (miRNA) is the novel fraction of non-coding RNA, which
is considered as the biological measure of genetic state of a cell. It plays a mantle regulatory role post
transcriptionally, involving both biological and pathologic cellular processes. miRNAs possess unique
properties like, abundant tissue expression which allows for reproducible isolation and quantification.
Methods: Literature search was carried out by using different combinations of keywords on Pub Med and
Cochrane database to retrieve the data for the literature review.
Discussion: Distinct expression profiles of miRNA in OSCC (Oral Squamous Cell Carcinoma) offers the
use of specific miRNAs signature for early-stage diagnosis, prediction and prognosis. It plays a critical role
in the initiation and progression of cancer functioning either as an oncogene or as tumor suppressor. At
present, it has a huge impact on understanding the aberrant gene modifications in OSCC and its future effects
on prognosis and therapeutic relevance needs to be looked upon.
Conclusion: Distinct phases of miRNA from its origin, properties, functionality, detection, cancer association
to future trends are updated in this review.

Author Biographies

Priya N S

Professor, Dept of Oral Pathology, V S Dental College & Hospital, Bangalore, K R Road, VV Puram,
Bangalore-56004

Ramakant Nayak

Professor & Principal, Dept of Oral Pathology & Microbiology, Maratha Mandal’s NGH
Institute of Dental Sciences & Research Centre, Belagavi

Vijayalakshmi K

Professor & HOD , Dept of Oral Pathology, Maratha
Mandal’s NGH Institute of Dental Sciences & Research Centre, Belagavi

Kishore Bhat

Professor & HOD, Dept of Molecular
biology and immunology, Maratha Mandal’s NGH Institute of Dental Sciences & Research Centre, Belagavi

Published

2021-05-17

How to Cite

Priya N S, Ramakant Nayak, Vijayalakshmi K, & Kishore Bhat. (2021). Imprints of miRNA- An Update. Indian Journal of Forensic Medicine & Toxicology, 15(3), 376-381. https://doi.org/10.37506/ijfmt.v15i3.15335