Gigantomastia Bilateral Induced Efavirenz: A Case Report


  • Amos Pongbulaan
  • Erwin Astha Triyono



Gigantomastia, Efavirenz, HIV, HAART


The prognosis of HIV-infection has improved dramatically since the introduction of Highly Active
Antiretroviral Therapy (HAART). With the need for a lifelong treatment, the longterm side effect of
antiretroviral agents is an emergent issue of concern. Gigantomastia is a rare condition characterized by
excessive breast growth. It may occur spontaneously, during puberty or pregnancy, or while taking certain
medications. HAART medications which probably associated with gigantomastia is efavirenz. A 25-yearold woman with HIV-infection who developed bilateral gigantomastia while receiving efavirenz-based
HAART regimens. The diagnosis was made after other possible causes of disease-induced gigantomastia
were exclude and confirmed by mammography. Surgical treatment has been considered after failure of
medical treatment. Although it is rare, physicians should be aware so that a timely diagnosis can be made.
In most cases, only conservative treatment is sufficient, but in severe cases surgical intervention might be

Author Biographies

Amos Pongbulaan

Resident, Department of Internal Medicine,  Faculty of Medicine Airlangga University, Surabaya Indonesia

Erwin Astha Triyono

2Doctor at Division of Tropical and Infection, Department of Internal
Medicine, Dr. Soetomo Hospital – Faculty of Medicine Airlangga University, Surabaya Indonesia



How to Cite

Amos Pongbulaan, & Erwin Astha Triyono. (2021). Gigantomastia Bilateral Induced Efavirenz: A Case Report. Indian Journal of Forensic Medicine & Toxicology, 15(3), 956-960.