Can Antisperm Antibodies affect Male Fertility after Subinguinal Varicocelectomy ? A Local Study

Abstract

Background: Antisperm Antibodies researches emerged in 1899 in a report referring to the ability of sperms
to be antigenic in case of injection into a foreign species. In 1900, researchers showed that sperms are also
antigenic in case of injection into similar species. Moreover, Wilson (1954) identified ASAB in the partners
of infertile male and then observed the association of ASAB with male infertility. In addition, a correlation
was found between ASAB and sperm proteomics, and thus researchers specified those ASABs decreasing
male fertilities via inhibition of the sperm functions crucial for fertilization.
Objectives: The study aimed at evaluating the effect(s) of varicocelectomy on the anti-sperm antibody in
cases who suffer from varicocele.
Methods: In the present prospective, controlled, clinical research which has been performed during the
period from april 2015 to may 2020. Therefore, the blood samples have been randomly provided from
190 males with mean age 33 years (ranging from 20-45 years) ,with the clinical varicocele who have been
indicated for varicocelectomy. Then, participants have been randomly selected from the urology outpatient
clinic of Al-Yarmouk Teaching Hospital in Baghdad,Iraq,and Al-Ramadi Teaching Hospital and private
clinic.
Results: In our study, ASA level (27.2%) with the positive serum ASA prior to with those (43.2%) following
the operation demonstrated a significant difference statistically (p = 0.033). However, such a result has been
not confirmed in the patients (27.4%) with positive semen ASA prior to with those (31.3%) following the
surgical operation (p = 0.881).
Conclusion: According to the results, varicocelectomy did not have any impact on the semen ASA,despite,
but serum antibody enhanced following varicocelectomy and sperm motility improved. Therefore,
varicocelectomy usefully affected the semen parameters in the infertile men suffering from varicocele.