Involvement of Insulin Like Growth Factor-I Gene Polymorphism with Diabetes and Diabetic Nephropathy in Individuals with Type 2 Diabetes in Babylon Province

Authors

  • Maytham Ahmed Abdul Aemah
  • Moaed Emran Al-Gazally
  • Ali Jasim Al-Sultani

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15459

Keywords:

insulin like growth factor-1,type 2 diabetes mellitus, diabetic nephropathy, polymorphism.

Abstract

Concerning type 2 diabetes mellitus (T2DM), diabetic nephropathy (DN) is a chiefmicrovascular complication.
Preceding studies have proposed that insulin-like growth factor-1(IGF-1) signaling might do a significant
role in DN. The existing study was implemented to explorethe allianceof single nucleotide polymorphism
(SNP) rs6214 of the IGF-1gene with T2DM and DN. The study consists of three groups, the first oneincludes
50 subjects, those were apparently healthy were considered as controls. The second oneinvolves 69 patients
with T2DM without nephropathy and the third oneencompasses 89 patients who suffer from T2DM with
DN. The analysis of results elucidated that thegenotype CT was decided to significantly increase the hazard
of T2DM by about 2 folds and the genotype TT was established to significantly increase the risk of DN by
about 3 folds with respect to those of the genotype CC. This study concludes that theSNPrs6214 of theIGF-1
gene associated with T2DM and DN.

Author Biographies

Maytham Ahmed Abdul Aemah

M.Sc., Biochemistry Department, College of Medicine, University of Babylon, Hillah,Iraq

Moaed Emran Al-Gazally

Prof., University of Al-Ameed, Iraq

Ali Jasim Al-Sultani

Assistant Prof., Biochemistry Department, College of Medicine, University of Babylon, Hillah

Published

2021-05-17

How to Cite

Abdul Aemah, M. A. ., Al-Gazally, M. E. ., & Al-Sultani, A. J. . (2021). Involvement of Insulin Like Growth Factor-I Gene Polymorphism with Diabetes and Diabetic Nephropathy in Individuals with Type 2 Diabetes in Babylon Province. Indian Journal of Forensic Medicine & Toxicology, 15(3), 1084-1093. https://doi.org/10.37506/ijfmt.v15i3.15459