The Effect of L- Carnitine on Cardiac Output in Patient with Chronic Kidney Disease on Regular Hemodialysis
Keywords:l-Carnitine, hemodialysis, cardiac output.
Background: L- carnitine deficiency is common in patients with chronic kidney disease, especially those
who are in regular dialysis. L- carnitine deficiency associated with high incidence of oxidative stress,
dyslipidemia and impaired cardiac performance. The present study tends to evaluate the effect of L-carnitine
supplement on cardiac output in patients with chronic kidney disease on regular hemodialysis.
Methods: the current study included 105 patients with chronic kidney disease, they were randomly selected
from patients attending artificial kidney unit at Al-Hussein Teaching Hospital in Thiqar city for regular
hemodialysis. They were divided into two groups, group I include 35 patients with chronic kidney disease
who did not receive L- carnitine and considered as control group, group II include 70 patients with chronic
kidney disease who receive L- carnitine. patients of group II further divided into two subgroups depending on
dose of L- carnitine. Group II(A), include 35 patients with chronic kidney disease who received L- carnitine
10/kg body weight one time daily and group II(B): include 35 patients with chronic kidney disease who
received L- carnitine 10/kg body weight two time daily. Ejection fraction was determined by transthoracic
echocardiography. Frequency, percentage, association, paired t-test were used for analysis of variables. All
variables represented by mean ± SD. P value of < 0.05 considered statistically significant.
Results: There was statistically significant increase in the mean of EF% (P<0.001) among patients with
chronic kidney disease who receive L- carnitine in a dose of 10mg/Kg body weight twice daily (group IIB)
after six months of treatment in comparison with the baseline values. There was a slight but significant (p<
0.05) increase in the mean of EF% in patients with chronic kidney disease who received single daily dose
of L- carnitine 10mg/Kg body weight (group IIA) after six months in comparison with the initial values at
the beginning of the study.
Conclusion: carnitine supplement in a suitable dose seem to improve cardiac performance among patients
with chronic kidney diseases on regular hemodialysis.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions