Assessment of Neuron Specific Enolase Level and some Related Biochemical Factors in Patients with Diabetic Peripheral Nerve Disorders
Keywords:Neuron Specific Enolase, Calprotectin, Xanthine Oxidase, diabetic neuropathy
Background: the disorder of neuron system by the action of hyperglycemia is Diabetic neuropathy
considers a common diabetic complication which is associated with a wide scope of clinical cases. Peripheral
neuropathy (PN) represents a clinical case, wherein the peripheral nervous system is damaged. Accordingly,
biochemical parameters have importance to apply as good predictor factors. Accordingly we attempt to
assess the biochemical factors of Neuron Specific Enolase NSE, Calpotectin CALP, Xanthine Oxidase XOD
in patients suffering from this type of diabetes complications as early predictors and study their correlations.
Methods: Fifty eight patients are known to have diabetic mellitus, which is classified into three groups.
Group I represents DPN of 30 patients, group II referred to 28 diabetic patients without DPN, in addition
to 30 healthy subjects as a control group, with range age (38-70) years old. BMI was determined for all the
studied groups. Levels of FBS, lipid categories and HbA1C were estimated. NSE, CALP and XOD levels
were measured by ELISA method. hs-CRP also determine for patients and control.
Results: The results revealed that levels of both FBS and HbA1C are increased significantly (p<0.05)
in both patients groups rather than healthy subjects. Moreover, results recorded an important increase of
cholesterol, TGs, LDL and VLDL levels (p<0.05). in contrast the HDL decrease in the two patient groups
related to healthy group. Increased levels of NSE, CALP, XOD and hs-CRP in DPN group and diabetic
group compared with control group. The results of this study showed a direct correlation between BMI and
FBS, in addition to BMI and hsCRP which possess the same correlation. Analysis by ROC curve showed that
both NSE and CALP are representing the strongest markers for diagnosis of diabetic neuropathy followed
by XOD and hs-CRP respectively.
Conclusion: Levels of the studied factors consider good indicators to use them as suitable markers for early
detection of diabetic sensory neuropathy. The results of ROC curve analysis revealed that NSE and CALP is
the strongest biomarker for diagnosis of diabetic neuropathy.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions