The Significance of Elevated Lactate Dehydrogenase and Creatine Kinase Activities as Prognostic Biomarkers for the Mortality in Patients with Terminal Cancers

Authors

  • Qasim J. AL-Daami
  • Hayder AA. Al-Hindy
  • Rzaq S. Kaurshead
  • Rawaa G. Abdullah

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15524

Keywords:

LDH, CK, cancer; toxicity; health.

Abstract

Background: Both creatine kinase (CK) and/or lactate dehydrogenase (LDH) mutually are elevated
significantly in many tumors. This study hypothesizes that LDH was evaluated as a prognostic factor for
survival time in patients with terminal cancer (PTC). Additionally, CK considered as a valuable in assessing
prognosis of advanced cancer patients. This study aimed to estimate the change in the CK/LDH levels
in patients with different types of cancer comparing with the controls, and to investigate their prognostic
significance for survival time termination in PTC.
Methodology: The study was performed at Cancer Central Research Clinic in Baghdad. We quantitated CK/
LDH using the colorimetric method in sixty PTC, and twenty age/sex-matched healthy adults.
Results: Serum values of CK/LDH were significantly increased in PTC compared to the controls (p<0.001).
There was a weak non-significant correlation between CKLDH in PTC and control. There was a nonsignificant
correlation of CK to LDH levels in different cancer types, except in patients with lymphatic
cancer.
Conclusion: In agreement with our hypothesis, serum levels of CK/LDH were significantly increased as the
patients approached death.

Author Biographies

Qasim J. AL-Daami

Lecturer, Ph.D; College of Pharmacy, University of Babylon, Iraq,

Hayder AA. Al-Hindy

Ass. Prof. Ph.D., College of Pharmacy, University of Babylon, Iraq

Rzaq S. Kaurshead

MSC., College of Medicine, Al Nahrain University, Iraq

Rawaa G. Abdullah

MSC., Shared Lecturer, College of Pharmacy, University of Babylon, Iraq

Published

2021-05-17

How to Cite

AL-Daami, Q. J. ., Al-Hindy, H. A. ., Kaurshead, R. S. ., & Abdullah, R. G. . (2021). The Significance of Elevated Lactate Dehydrogenase and Creatine Kinase Activities as Prognostic Biomarkers for the Mortality in Patients with Terminal Cancers. Indian Journal of Forensic Medicine & Toxicology, 15(3), 1536-1542. https://doi.org/10.37506/ijfmt.v15i3.15524