Outcome of Using Medical Grade Calcium Sulfate Hemihydrate (DentoGen) in Unilateral Alveolar Cleft Repair
Keywords:Alveolar cleft, autogenous bone graft, DentoGen.
Objectives: The aim of this prospective study was to evaluate the efficacy of fast setting (DentoGen) bone
substitute for secondary alveolar cleft repair.
Materials and Methods: Ten patients with complete unilateral cleft lip and palate were included for alveolar
cleft repair with fast setting (DentoGen) without autogenous bone graft in 2017 and 2018. Pre-operation and
6 months post-operation CBCT were used for measurement of bone density and bone volume in cleft site.
The data was analyzed by using Pearson’s correlation coefficient test and paired sample t-test via SPSS
software version 24.
Results: The mean age of patients in this study was 10.4±2.657 years. The pre-operative mean alveolar cleft
volume was 0.8996±0.117cm3. Six months after grafting with fast setting (DentoGen) graft, satisfactory
bone formation was observed in all patients except two patients. The mean bone density of cleft site was
303±42.843 HU which was significantly lower than the non-cleft side, and the mean percentage of new bone
formation was 64.74±10.290% compared with original cleft volume.
Conclusion: Calcium sulfate hemihydrate (DentoGen) can represent a promising alternative to autogenous
bone graft in repairing small unilateral alveolar cleft during mixed dentition.
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