Evaluation of Glycogen Phosphorylase BB (GPBB) Level in Serum as Marker in Diagnosis of Acute Ischemic Stroke

Authors

  • Gheyath AlGawwam
  • Zeena abdul Iilah
  • Maryam Emad Shake

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15534

Keywords:

Acute ischemic stroke; patiants; toxicity; glycogen phosphorylase BB; serum

Abstract

Objective: We aimed to investigate whether Serum levels of glycogen phosphorylase BB (GPBB) isoform
could be used as a potential diagnostic biomarker in Acute Ischemic Stroke (AIS) patients or not.
Materials and methods : glycogen phosphorylase BB were prospectively evaluated in 40 patients aged
between 40 to 70 y who were admitted within 24 h of the onset of AIS. The control group included 40
healthy volunteers of similar age without any disease.
Results: There is a significant elevation in the level of GPBB in ischemic stroke group and compared with
control group. For Control, the observations of GPBB had an Min = 4.91 For Stroke, the observations of
GPBB had an Min = 15.32
There was a significant positive correlation between stoke and Glycogen phosphorylase (rpb = 0.7473,
p< .001). The correlation coefficient between Stroke and Glycogen phosphorylase was 0.7473 indicating
a large effect size. This indicates that moving from the Not having to having Stroke is associated with
an increase in Glycogen phosphorylase. Therefore, Stroke tends to be associated with higher values of
Glycogen phosphorylase
Conclusions: 1-This study shows there is significant elevation in enzyme level of glycogen phosphorylase
BB (GPBB) in ischemic stroke group and compared with control group.

Author Biographies

Gheyath AlGawwam

Assistance Prof Dr. Medical Department / Baghdad University / College of Medicine, Iraq

Zeena abdul Iilah

Lecturer Dr. Clinical Biochemistry/ Al- Nahrain University/ College of medicine/ Department of Chemistry and Biochemistry, Iraq

Maryam Emad Shake

Post Graduate In Al- Nahrain university/ College of Medicine, Iraq

Published

2021-05-17

How to Cite

AlGawwam, G. ., Iilah, Z. abdul ., & Shake, M. E. . (2021). Evaluation of Glycogen Phosphorylase BB (GPBB) Level in Serum as Marker in Diagnosis of Acute Ischemic Stroke. Indian Journal of Forensic Medicine & Toxicology, 15(3), 1603-1608. https://doi.org/10.37506/ijfmt.v15i3.15534