Evaluation of Glycogen Phosphorylase BB (GPBB) Level in Serum as Marker in Diagnosis of Acute Ischemic Stroke
Keywords:Acute ischemic stroke; patiants; toxicity; glycogen phosphorylase BB; serum
Objective: We aimed to investigate whether Serum levels of glycogen phosphorylase BB (GPBB) isoform
could be used as a potential diagnostic biomarker in Acute Ischemic Stroke (AIS) patients or not.
Materials and methods : glycogen phosphorylase BB were prospectively evaluated in 40 patients aged
between 40 to 70 y who were admitted within 24 h of the onset of AIS. The control group included 40
healthy volunteers of similar age without any disease.
Results: There is a significant elevation in the level of GPBB in ischemic stroke group and compared with
control group. For Control, the observations of GPBB had an Min = 4.91 For Stroke, the observations of
GPBB had an Min = 15.32
There was a significant positive correlation between stoke and Glycogen phosphorylase (rpb = 0.7473,
p< .001). The correlation coefficient between Stroke and Glycogen phosphorylase was 0.7473 indicating
a large effect size. This indicates that moving from the Not having to having Stroke is associated with
an increase in Glycogen phosphorylase. Therefore, Stroke tends to be associated with higher values of
Conclusions: 1-This study shows there is significant elevation in enzyme level of glycogen phosphorylase
BB (GPBB) in ischemic stroke group and compared with control group.
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