Evaluation of the Diagnostic Role of Gata3 Immunohistochemistry on Cytology Specimens for Metastatic Breast Carcinoma
Keywords:: Breast carcinoma, Cytology, Fine needle aspiration, GATA3, Immunohistochemistry
Objective: Distinguishing of metastatic breast carcinoma from nonmammary metastatic carcinomas by
cytological examination might have some difficulties. The sensitivity of traditional tumor markers for
immunostaining might be not high enough . The role of GATA3 immunohistochemistry as a novel marker
of primary and metastatic stages of breast carcinoma in specimens of fine needle aspiration was evaluated.
Materials and Methods: Sections were taken from 73 cases of FNA samples of metastatic malignancies
including 38 metastatic breast cancer and 35 nonmammary malignancies were stained with GATA3
immunohistochemical marker. Samples of FNA were taken from pleural effusion, ascetic fluid and lymph
Results: Eighty-nine percent (34/38) of metastatic breast carcinoma cases were regarded as GATA3 positive
expression , while all nonmammary adenocarcinoma samples were GATA3 negative . Most of GATA3
positive samples showed intense nuclear staining in the majurity of the malignant cells.
Conclusions: GATA3 staining is an important addition to immunohistochemical panels for fine needle
aspiration samples for distinguishing metastatic breast carcinoma from other malignancy.
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