Evaluation of the Role of Pentraxin 3, B-type Natriuretic Peptide and Troponin I in Acute Carbon Monoxide Cardiotoxicity

Authors

  • Alaa Essam Mahmoud
  • Suzan Mostafa Mahmoud
  • Mona El KotbMoussa
  • AyaShawky Khater

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15561

Keywords:

Cardiotoxicity, acute carbon monoxide poisoning, BNP, Pentraxin 3, Troponin I

Abstract

Background: Acute carbon monoxide induced cardiotoxicity is one of the main causes of mortality. It
is considered as a poor prognostic factor in patients with carbon monoxide intoxication.Although early
diagnosis of cardiac injury is often difficult and might be misdiagnosed.
This study aimed to assess the role of Pentraxin 3 and B-type natriuretic peptide in comparison with cardiac
Troponin I as early predictors of cardiotoxicity in patients presented with acute CO poisoning.
Methods: Thirty patients with acute CO poisoning were recruited from PoisonControl Center, Ain Shams
University Hospitals. Serum levels of Cardiac biomarkers (Pentraxin3, BNP and Troponin I) were measured
on admission and after 10 hours after exposure.
Conclusion: Our results revealed that, B-type natriuretic peptide and Troponin I were more reliable cardiac
biomarkers in early prediction of cardiotoxicity in acute CO poisoning patients.While Pentraxin3 had low
sensitivity and specificity to predict the cardiotoxicity in acute CO poisoning in comparing with BNP and
Troponin I

Author Biographies

Alaa Essam Mahmoud

Assistant Lecturer,  Department of Forensic Medicine and Clinical
Toxicology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Suzan Mostafa Mahmoud

Professor,Department of Forensic Medicine and Clinical
Toxicology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Mona El KotbMoussa

Professor,  Department of Forensic Medicine and Clinical
Toxicology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

AyaShawky Khater

Assistant Professor, Department of Forensic Medicine and Clinical
Toxicology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Published

2021-05-17

How to Cite

Alaa Essam Mahmoud, Suzan Mostafa Mahmoud, Mona El KotbMoussa, & AyaShawky Khater. (2021). Evaluation of the Role of Pentraxin 3, B-type Natriuretic Peptide and Troponin I in Acute Carbon Monoxide Cardiotoxicity. Indian Journal of Forensic Medicine & Toxicology, 15(3), 1725-1732. https://doi.org/10.37506/ijfmt.v15i3.15561