Carpal Tunnel Syndrome and Calcium Deposit in Surgically Transacted Transverse Carpal Ligament
Keywords:Carpal tunnel syndrome, cadmium, calcium, lead, ICP-MS
A diagnosis of carpal tunnel syndrome (CTS) in a human often contains more than one test. Calcification
of the carpal transverse ligaments (TCL) is one of the common reasons why patients seek CTS surgery.
However, determination of calcium (Ca) concentration in TCL has not been studied, and results of
environmental toxicity studies assessing the relationship between Ca, and elemental deposition in TCL
are inconsistent. The purpose of this paper was to verify this hypothesis by conducting a chemical analysis
of a portion of the released TCL to assess whether there is a relationship between CTS and Ca, measured
as the total concentration of Ca, and to measure the precipitation of elements, the most closely related
elements associated with Ca and toxic are cadmium and lead. Surgical release of TCL was performed on
forty patients, and total concentrations of Ca, Cd and Pb in the extracted portion of TCL were digested and
determined using inductively coupled plasma mass spectrometry (ICP-MS) and the possibility of using X-ray
spectroscopy (XRF) for direct elemental analysis. Ca mineralization revealed in some TCLs. In assessing
patients’ environmental pollution, it was observed that the Cd and Pb concentrations were significant with
the higher Ca concentration, and XRF was useful for direct detection of the elements in samples of human
body. In conclusion, these results indicate that TCL mineralization by Ca does not characterize CTS, which
has important concerns in improving patients’ therapeutic strategies, and Cd and Pb concentrations varied
due to different factors.
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