Promising Cytotoxicity and Anticancer Activity of Capsicum Annuum

Authors

  • Ali Al-Samydai
  • Yasser KhalilBustanji
  • Hanan Azzam
  • Farah Al-Mamoori
  • Deniz M. Al-Tawalbe
  • Bashaer Abu-Irmaileh
  • Talal Aburjai

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15570

Keywords:

Capsicum annuum, cancer, HPLC, extraction, qualitative analysis, quantitative analysis

Abstract

Background: Cancer is the second leading cause of death globally. Most of the anticancer drugs showed poor
selectivity. Medicinal plants have proven, historically, their value as a source of molecules with therapeutic
potential. Aim and objective: This study aims to optimize the method of extraction, identification, qualitative
and quantitative analysis of Capsaicin (CAP) from Jordanian Capsicum annuum (C. annuum), and to
investigate the anticancer activity of the crude extract.Methods: The plants extract from C. annuum was
obtained by Soxhlet extraction, HPLC were used for qualitative and quantitative analysis, and Cytotoxic
potentials was investigated by Cell viability (MTT).Results: Our results showed that Hexan solvent
represented a convenient yield of extraction and the highest percentage of CAP yield with better purity of
extract in comparison with other solvents, Jordan Valley ‘’Al-Ghor’’ showed the highest percentage of CAP
yield in extract. Additionally, C. annuum crude extract showed dose depended cytotoxicity activity against
a cancer cell. Conclusion, we have optimized the isolated, qualitative and quantitative analysis of CAP from
the fruits of C. annuum growing in Jordan in fast and reproducible method.

Author Biographies

Ali Al-Samydai

Assistant Professor, Department of Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, AlAhliyya Amman University, Amman, 19328, Jordan, 

Yasser KhalilBustanji

Professor, Department of Pharmaceutical Sciences, Faculty
of Pharmacy, University of Jordan, Amman, 11942, Jordan,

Hanan Azzam

Researcher, Hamdi Mango Center for Scientific
Research (HMCSR), University of Jordan, 11942, Amman, Jordan

Farah Al-Mamoori


Assistant Professor, Faculty of Pharmacy,
Zarqa University, P.O. Box 132222, Zarqa, 13132, Jordan

Deniz M. Al-Tawalbe

Assistant Professor, Department of Applied Sciences,
Faculty of Irbid University, Al-Balqa Applied University, Salt, 19117, Jordan

Bashaer Abu-Irmaileh

Researcher, Hamdi Mango Center for Scientific
Research (HMCSR), University of Jordan, 11942, Amman, Jordan

Talal Aburjai

Professor, Department of Pharmaceutical Sciences, Faculty
of Pharmacy, University of Jordan, Amman, 11942, Jordan

Published

2021-05-17

How to Cite

Ali Al-Samydai, Yasser KhalilBustanji, Hanan Azzam, Farah Al-Mamoori, Deniz M. Al-Tawalbe, Bashaer Abu-Irmaileh, & Talal Aburjai. (2021). Promising Cytotoxicity and Anticancer Activity of Capsicum Annuum. Indian Journal of Forensic Medicine & Toxicology, 15(3), 1766-1775. https://doi.org/10.37506/ijfmt.v15i3.15570

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