Is There is a Correlation between Vitamin D Status and Glycemic Control (HBa1c) in Patients with Type 2 Diabetes Mellitus: Review Article with Meta-Analysis
Keywords:vitamin D status, Hba1c, diabetes type 2, andmeta-analysis
Background and Purpose: Diabetes mellitus type 2 represent significant problem for health care givers
because of its huge prevalence.The clue for non-skeletal impact of vitamin D become increasing suggesting
the potential benefit in many diseases related to cardiac system, immunity disorders and diabetes mellitus
type 2.We achieved this systematic review containing cross-sectional studies to assess the association
between vitamin D status glycaemiaindex as represented by glycosylated hemoglobin.
Method: We achieved literature search for cross-sectional studies which consider the impact of status of
vitamin D on HBa1c as major outcome of interest. The author targets database like Medline and google
scholar database for cross-sectional trials for period up to December 2020. The software utilized to analyze
the data statistically was comprehensive meta-analysis (CMA).
Results: Eighteen clinical trials have been identified by search.Thirteen studies found the inverse correlation
between glycemic index (HBa1c) and patient’s status of vitamin D.It was founded that the overall combined
influence of vitamin D level on glycosylated hemoglobinwas significant (p = 0.001, and 95% CI: - 0.230 to
Conclusion: The current review revealed that the impact of status of vitamin D in correction of glycaemia
was significant. Thepatient’s vitamin D status can has important impact on the pathogenesis of T2DM.
The diabetic patients with poor indices of glycaemia has higher prevalence of decreased vitamin D level
referring to potential benefit of vitamin D in correction of such indices.
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