GATA 3 Reactivity in Adenoid Cystic Carcinoma and Pleomorphic Adenoma of Salivary Glands

Authors

  • Ali Zaki NAJI
  • Ammar Eesa Mahdi

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15575

Keywords:

pleomorphic adenoma, adenoid cystic carcinoma, GATA-binding protein 3 , immunohistochemistry.

Abstract

Objectives:The main targets is evaluate clinicopathological distribution and comparison of
immunohistochemical (IHC) expression of GATA 3 between in adenoid cystic carcinoma (ACC) and
pleomorphic adenoma (PA) of salivary . Design and Methods: This retrospective analysis, open surgical
specimens of salivary gland that were done , and consisting of 150 cases that divided into three groups:
normal salivary gland tissues (n=50), adenoid cystic carcinoma(n=50), and pleomorphic adenoma(n=50).
Clinical data (age, sex, previous diseases ), physical examination, and investigations are done for all patients.
In addition.These 150 cases of paraffin embedding blocks of salivary tissue were stained by ordinary stained
(hematoxylin and eosin staining ). Manual IHC staining of GATA 3 was done. Results: Age groups is
younger for normal salivary gland tissues than PA, and ACC . Sex distribution was slightly increase in
male in comparison to female in normal salivary gland tissues and PA. GATA 3 staining was showing more
positivity in normal salivary gland tissues (43/50 patients) than PA (27/50 patients) and ACC (14/50 patients).
This positivity in GATA 3 IHC staining were more in male sex, regarding 55.8% in normal salivary gland
tissues than ACC50% and PA 51.9% . Age group 31-40, 40-50 and 61-70 years were showing more positive
GATA 3 IHC staining in normal salivary gland tissues, PA, and ACC respectively. there was insignificant
association between GATA 3 IHC staining with either age groups or sex groups distribution .Conclusion:
GATA3 IHC is good marker and can used for searching salivary gland tumor origin, assisting in diagnosis
Salivary gland tumors subtypes but GATA3 IHC staining has no association to specific sex or age groups in
Salivary gland tumors. Usage of surgical operations for histopathological specimens preparation are better
and give good efficiency for IHC markers staining.

Author Biographies

Ali Zaki NAJI

Basic Science Dept. , College of Dentistry, University of Babylon, Assistance professor, F.I.B.M.S pathology,
Hilla City, Babylon Province, Iraq,

Ammar Eesa Mahdi

Basic Science Dept. , College of Dentistry, University of Babylon, Assistance
Lecturer, M.Sc. Histopathology, Hilla City, Babylon Province, Iraq

Published

2021-05-17

How to Cite

Ali Zaki NAJI, & Ammar Eesa Mahdi. (2021). GATA 3 Reactivity in Adenoid Cystic Carcinoma and Pleomorphic Adenoma of Salivary Glands. Indian Journal of Forensic Medicine & Toxicology, 15(3), 1789-1794. https://doi.org/10.37506/ijfmt.v15i3.15575