Design and Synthesis of Sulindac New Derivitives as Possible Mutual Prodrug with Potential to Maximized Therapeutic Area

Authors

  • Ahmed Kareem Hussein Mubarak
  • Ahmed Wheed Radhi Alhasnaway
  • Haider F.S. Al-zubaidy

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15600

Keywords:

sulindac , antioxidants, anticancer, mutual prodrug.

Abstract

The urgent necessity today for development of anti cancer agent is crucial so highly dependent for searching
for new anti neoplastic action ,the drug discovery process is costly and consume long time ,in my study
focusing my efforts toward drug optimization process using sulindac (NSAID) which has a fantastic
attractive area as anti cancer and anticancer in addition to it is anti inflammatory action .
The study describes design and synthesis of mutual pro-drug of sulindac in combination with thenatural
anti oxidants (menthol ,thymol ,vanillin,guiacol) as a single integral pharmaceutical unit byan chloro acetyl
chlorideas spacer to form an ester mutual prodrug with expected to improve the anti inflammatory ,anti
cancer , antioxidant action of sulindac by the conjugation with natural anti oxidative integral moiety and
minimized the ulcerogenic adverse effect of sulindacit is carboxylic acid functionality .The synthesis is
conferred byH1NMR, FT-IR, CHN and physiochemical properties.

Author Biographies

Ahmed Kareem Hussein Mubarak

Lecturer, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Kufa, Najaf, Iraq

Ahmed Wheed Radhi Alhasnaway

Lecturer, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Kufa, Najaf, Iraq

Haider F.S. Al-zubaidy

Lecturer, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Kufa, Najaf, Iraq

Published

2021-05-17

How to Cite

Hussein Mubarak, A. K. ., Radhi Alhasnaway, A. W. ., & Al-zubaidy, H. F. (2021). Design and Synthesis of Sulindac New Derivitives as Possible Mutual Prodrug with Potential to Maximized Therapeutic Area. Indian Journal of Forensic Medicine & Toxicology, 15(3), 1956-1962. https://doi.org/10.37506/ijfmt.v15i3.15600