Histological Effect of Onion, Tea Against Lead Acetate in Some Organs of Sprague–Dawley Rats
Keywords:Lead (Pb) acetate toxicity; Onion; Tea; Kidney; Liver.
The study aimed to investigate the negative effects of lead acetate on the liver and kidneys tissues of male
Sprague Dawley rats. It was conducted on 28 male rats of the aforementioned strain. The rats were divided
into four groups, including the control group (provided with regular fodd only), lead acetate group (LD 50),
onion group (provided with lead with water and dried onion powder at a rate of 4% with the fodd) and tea
group (provided with lead with water and tea powder at 1% with the fodd). The results of the current study
showed that the control group was a normal marker of hepatocytes (Central Vein, Sinosoid, Hepatocyte)
While we note that the results of the T2 group, we find that there is severe damage to the tissues of the
liver cells. Through the results of the study, we find the occurrence of a large grouping of lymphocytes and
severe congestion. Hepatocytes, the results of the T4 group showed hemorrhage and no accumulation of
lymphocytes, as was the case in the results of the T2 group. Regarding the sections of renal tissue, the results
of the study showed that the control group had normal tissues as well as parts of the kidneys (Bowmans
Capsule, glomerulus, Distal, convoluted tubule, Proximal convoluted tubules), while the renal tissue for T2
suffered from severe hemorrhage and very severe cell damage, and compared with the results of T3, we find
that the renal tissue of T3 is distinguished by the presence of partially shrink glomerular and is not better
than both T2 and T4 tissues, which are characterized by a clear shrinkage of the glomeruli and the presence
of hemorrhage, but with less than T3. Therefore, we find that the best results in terms of therapeutic nutrition
for liver cells are T4 (tea 1%) and kidney T3 cells (onion 4%).
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