Efficacy of Five Organic Acids Combination on T2- Mycotoxicosis in Rats

Authors

  • Ammar A. Fadhil
  • Suhair Hassan Alkutbi
  • Eman S. Nassir

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15624

Keywords:

Histopathological lesions, Hepatoxicity, Oxidoreductive stress, T-2 mycotoxin, X-MoldCid®

Abstract

Mycotoxins are secondary by-products of mold metabolism and are accountable for human and animal
mycotoxicosis. The most serious trichothecenic mycotoxin is the fungal T-2 mycotoxin. T-2 mycotoxin
impaired nutrient absorption, metabolism, and then, eliciting severe oxidoreductive stress. Diet plays a key
role beyond the supply of nutrients in order to promote animal and human health. Organic acids have been
commonly used to exert antioxidative stress capacity in the liver and gut ecosystem. This study is planned to
explore, the competence of using (X-MoldCid®) during chronic T-2 mycotoxicosis course in rat. Rats were
allocated into 4 main groups, (CN-Gr), negative control and was allowed for the free access to the normal
rats chow and the tap water for 90 days. (OAC-Gr), which was assigned as the organic acids positive control
and was allowed for the free access to normal rat chow and (X-MoldCid®) in the tap water for 90 days
.Group 3 or (T2-Gr) and was given the T2 contaminated chow ad libitum and group 4 (T2+OAC-Gr) .Each
one of the four groups was subdivided into two subgroups (n=7) that one was sacrificed on day 45 (Subgroup
A) meantime the remaining rats (Subgroup B) maintained until finishing of the entire study period (90 days).
In T2 intoxicated group, liver histopathological findings revealed, lesions of reversible types (hydropic and
fatty degenerations) while intestinal histopathological findings revealed, lesions of hyperactive goblet cells
with sever slaughing of epithelia. In T2+OAC-Gr, the ultimate efficacy of organic acids success in limiting
the apoptotic activity and preventing hepatic necroinflammatory changes which were in accordance with
the improvement of antioxidative status, liver and intestinal function enzymes and other serum biochemical
estimated tests. The total results of this study have been clarified the regenerative and antioxidant potentials
of (X-MoldCid®) in coping with T2-toxin mediated intestinal lesions and hepatotoxicityin rats.

Author Biographies

Ammar A. Fadhil

Tutor, Department of Pharmacology & Toxicology,  Department of Clinical Laboratory Sciences,
College of Pharmacy-University of Baghdad-Baghdad, Iraq

Suhair Hassan Alkutbi

Tutor, Department of Clinical Laboratory Sciences,
College of Pharmacy-University of Baghdad-Baghdad, Iraq

Eman S. Nassir

Tutor, Department of Clinical Laboratory Sciences,
College of Pharmacy-University of Baghdad-Baghdad, Iraq

Published

2021-05-17

How to Cite

Ammar A. Fadhil, Suhair Hassan Alkutbi, & Eman S. Nassir. (2021). Efficacy of Five Organic Acids Combination on T2- Mycotoxicosis in Rats. Indian Journal of Forensic Medicine & Toxicology, 15(3), 2081-2094. https://doi.org/10.37506/ijfmt.v15i3.15624