The Role of Reactive Oxygen Species and Bacterial Infections in Male in Male Infertility in Al- Anbar Province / West of Iraq
Keywords:Male infertility, ROS, Bacterial infection
In the male genital tract, spermatozoa and leukocytes, including neutrophils and macrophages, generate
reactive oxygen species (ROS). ROS is involved in the regulation of sperm functions, such as acrosome
reactions and capacitation. Infections result in excessive ROS production, resulting in a ‘oxidative burst’
of neutrophils/macrophages as a first-line defense mechanism. During infection, the imbalance of pro-and
antioxidants favoring the former results in oxidative stress that impairs the sperm functions mentioned In
addition to motility and fertilization. ROS produced during testis and epididymis infections is especially
harmful to sperm due to longer contact time and lack of antioxidant protection. Only very high numbers of
ROS-producing leukocytes are harmful to sperm functions in the final ejaculate.
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