Evaluation of Serum Level of Cystatin C and Fetuin A in Patients with Chronic Renal Failure

Authors

  • Marwa Nabeel Hameed
  • Khudhair A. Khudhair
  • Yasir I. abbas

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15646

Keywords:

Fetuin-A ; CKD; Cystatin; Hemodialysis

Abstract

The study found that, serum fetuin-A was significantly reduced in CKD patients before dialysis (19.07±4.24
ng/ml) as compared with healthy individuals (22.5±5.94 ng/ml), P<0.01 and in CKD patients after dialysis
(19.74±4.25 ng/ml) as compared with healthy individuals. The study found that, serum cystatin C was
significantly reduced in CKD patients before dialysis (12.95±1.54 ng/ml) as compared with healthy individuals
(8.16±2.37 ng/ml), P<0.01 and in CKD patients after dialysis (12.39±1.66 ng/ml) as compared with healthy
individuals. The study showed a significant negative correlation between CKD patients before dialysis and
after dialysis regarding cystatine C (r: -0.37). The study found that, blood urea was significantly increased
in CKD patients before dialysis (164.3±30.1 mg/dl) as compared with healthy individuals (24.9±3.7 mg/dl),
P<0.01 and in CKD patients after (76.1±29.2 mg/dl) as compared with healthy individuals and there was a
significant difference in B. urea between CKD patients before and after dialysis (P<0.01). The study also
indicated that S. creatinine was significantly increased in CKD patients before dialysis (5.61±1.99 mg/dl)
followed by patients after dialysis (3.43±1.47 mg/dl) as compared with healthy individuals (0.57±0.24 mg/
dl) (P<0.01). The study showed a significant negative correlation between of Fetuin-A level with B. urea, S.
creatinine and S. cysteine in CKD patients before dialysis and after dialysis

Author Biographies

Marwa Nabeel Hameed

M. Sc. Medical Biochemistry, Kirkuk Health Directorate, Iraq

Khudhair A. Khudhair

Prof. Dr. Biochemistry, College of Medicine, Tikrit
University, Iraq

Yasir I. abbas

Assistant Prof. Dr. Urology. College of Medicine, Tikrit University, Iraq

Published

2021-05-17

How to Cite

Marwa Nabeel Hameed, Khudhair A. Khudhair, & Yasir I. abbas. (2021). Evaluation of Serum Level of Cystatin C and Fetuin A in Patients with Chronic Renal Failure. Indian Journal of Forensic Medicine & Toxicology, 15(3), 2226-2234. https://doi.org/10.37506/ijfmt.v15i3.15646