The Study of Hemodialysis on the Change Rate of Serum Osteopontin, Sialic Acid, and Nitric Oxide Levels

Authors

  • Entedhar R. Sarhat
  • Takea Shaker Ahmed
  • Mahde Salih Hamad
  • Rajaa S. Najim
  • ThuraiaRifaat Sarhat
  • Kasim Sakran Abass

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15686

Keywords:

Hemodialysis; Osteopontin; Chronic renal failure

Abstract

Objective : Chronic renal failure (CRF) is one of the most prevalent diseases of human societies, especially
in Iraq. Despite all advances that have been made so far, hemodialysis with all its complications is being
applied as the novel treatment strategy for such individuals.Osteopontin (OPN) is a multi-functional secreted
glycoprotein that plays a crucial role in and inflammatory process.
Our aim was to ascertain whether circulating osteopontin,sialic acid ,and NO levels are altered in patients
with CRF before and after dialysis.
Design and Methods: A total of 126 patients with HD were enrolled in this study. Serum OPN levels were
measured using a commercial enzymelinked immunosorbent assay kit.
Results: Osteopontin and Sialic acid levels were significantly higher in haemodialysed CKD patients than
predialysed CKD patients and normal healthy controls. The levels of NO was significantly lower in CRF
patients pre HD when compared with healthy controls and significantly increased in post HD as compared
to pre HD.
Conclusion: In our study, OPN SA, NO were found to be a valuable marker of severity of CKD.

Author Biographies

Entedhar R. Sarhat

Department of Basic Science, Dentistry College, University of Tikrit, Tikrit, Iraq,

Takea Shaker Ahmed

Department of Basic Science, Dentistry College, University of Tikrit, Tikrit, Iraq

Mahde Salih Hamad

Department of Basic Science, Dentistry College, University of Tikrit, Tikrit, Iraq

Rajaa S. Najim

Department of Basic Science, Dentistry College, University of Tikrit, Tikrit, Iraq

ThuraiaRifaat Sarhat

College of Education,
University of Tikrit, Tikrit, Iraq

Kasim Sakran Abass

Department of Pharmacology and Toxicology, College of Pharmacy, University of
Kirkuk, Kirkuk, Iraq

Published

2021-05-17

How to Cite

Entedhar R. Sarhat, Takea Shaker Ahmed, Mahde Salih Hamad, Rajaa S. Najim, ThuraiaRifaat Sarhat, & Kasim Sakran Abass. (2021). The Study of Hemodialysis on the Change Rate of Serum Osteopontin, Sialic Acid, and Nitric Oxide Levels. Indian Journal of Forensic Medicine & Toxicology, 15(3), 2521-2528. https://doi.org/10.37506/ijfmt.v15i3.15686