The Study of Hemodialysis on the Change Rate of Serum Osteopontin, Sialic Acid, and Nitric Oxide Levels

Abstract

Objective : Chronic renal failure (CRF) is one of the most prevalent diseases of human societies, especially
in Iraq. Despite all advances that have been made so far, hemodialysis with all its complications is being
applied as the novel treatment strategy for such individuals.Osteopontin (OPN) is a multi-functional secreted
glycoprotein that plays a crucial role in and inflammatory process.
Our aim was to ascertain whether circulating osteopontin,sialic acid ,and NO levels are altered in patients
with CRF before and after dialysis.
Design and Methods: A total of 126 patients with HD were enrolled in this study. Serum OPN levels were
measured using a commercial enzymelinked immunosorbent assay kit.
Results: Osteopontin and Sialic acid levels were significantly higher in haemodialysed CKD patients than
predialysed CKD patients and normal healthy controls. The levels of NO was significantly lower in CRF
patients pre HD when compared with healthy controls and significantly increased in post HD as compared
to pre HD.
Conclusion: In our study, OPN SA, NO were found to be a valuable marker of severity of CKD.