The Impact of OCA2 (rs1800407) and HERC2 (rs12913832) Gene Polymorphisms on Iris Color in a Sample of Iraqi People

Authors

  • Tabarek Mundher Noaman
  • Abdul Kareem A. Alkazaz

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15698

Keywords:

OCA2, rs1800407, HERC2, rs12913832, Gene Polymorphisms, Iris Color

Abstract

The study was directed in order to determine Single Nucleotide Polymorphisms (SNPs) (rs1800407 G>A)
of OCA2 and (rs12913832 A>G) HERC2 genes and their association as a DNA marker with eye color in 60
samples of Iraqi people. Samples were collected from College of Science / University of Baghdad and also
people from different areas of Baghdad, Iraq; during the two months period from September to November
2020. These SNPs determination was carried out by using quantitative real-time polymerase chain reaction
(qPCR) of blood samples. The results of rs12913832 genotype showed significantly differences (p<0.05) in
the green eye color group. A Survey of HERC2 gene SNP genotypes and allele frequencies in the black and
green iris groups showed that there was a significant variation in the wild type (AA) and homozygous mutant
(GG) genotype frequencies in (rs 12913832), while the SNP (rs1800407) of OCA2 concluded that gene may
have a non-significant effect among a sample of this study comparing with green eye to black eye color.

Author Biographies

Tabarek Mundher Noaman

Scholar Researcher, Dept. of Biotechnology, College of Science, University of Baghdad, Iraq

Abdul Kareem A. Alkazaz

Prof., Dept. of Biotechnology, College of Science, University of Baghdad, Iraq

Published

2021-05-17

How to Cite

Noaman, T. M. ., & A. Alkazaz, A. K. . (2021). The Impact of OCA2 (rs1800407) and HERC2 (rs12913832) Gene Polymorphisms on Iris Color in a Sample of Iraqi People. Indian Journal of Forensic Medicine & Toxicology, 15(3), 2605-2610. https://doi.org/10.37506/ijfmt.v15i3.15698