The Dynamics of Macrophage Function in Reparation of Natural Immune System in Tuberculosis Disease

Authors

  • Christina Destri
  • Jusak Nugraha
  • Muhammad Amin
  • Djoko Agus Purwanto

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15720

Keywords:

Natural immunity; macrophages; tuberculosis

Abstract

Macrophages related with pathogen was involved the ability of Mycobacterium tuberculosis (Mtb) to
developing mechanisms to prevent macrophage attacks and the aim of this study was to find the relationship
between specific role of macrophages in natural immune system in tuberculosis (TB) disease. The research
design of this study used literature reviews from various journals and it was accessed in Google Scholar
and various medical science websites who bublessed less than 10 years. Localization of mycobacteria in
granulomas form and activation of macrophages ability to kill and eliminate pathogens also the movement of
M1 to M2 polarization as an important part for the host to prevent widespread tissue damage. However, the
loss of the immune system suppression by M1 and Th1 molecules will give benefit to fertility development
of Mtb in the environment of immunity M2 / Th2. The results of this study showed that the dynamics of
macrophages in tuberculosis disease is a balance of Mtb’s ability to escape from the immune system. The
effectiveness of anti-TB treatment repair the immune system and eliminate Mtb

Author Biographies

Christina Destri

Doctoral Student. Doctoral Program of Medical Science, Faculty of Medicine, Airlangga University, Indonesia

Jusak Nugraha

Professsor, Department of Clinical Patology, Faculty of Medicine, Airlangga University, Indonesia, 

Muhammad Amin


Professsor
Department of Internal Medicine, Faculty of Medicine, Airlangga University, Indonesia, 

Djoko Agus Purwanto

Professsor, Department
of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Indonesia

Published

2021-05-17

How to Cite

Christina Destri, Jusak Nugraha, Muhammad Amin, & Djoko Agus Purwanto. (2021). The Dynamics of Macrophage Function in Reparation of Natural Immune System in Tuberculosis Disease. Indian Journal of Forensic Medicine & Toxicology, 15(3), 2724-2732. https://doi.org/10.37506/ijfmt.v15i3.15720

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