GATA 3 Reactivity in Adenoid Cystic Carcinoma and Pleomorphic Adenoma of Salivary Glands
Keywords:pleomorphic adenoma, adenoid cystic carcinoma, GATA-binding protein 3 , immunohistochemistry
Objectives: The main targets is evaluate clinicopathological distribution and comparison of
immunohistochemical (IHC) expression of GATA 3 between in adenoid cystic carcinoma (ACC) and
pleomorphic adenoma (PA) of salivary . Design and Methods: This retrospective analysis, open surgical
specimens of salivary gland that were done , and consisting of 150 cases that divided into three groups:
normal salivary gland tissues (n=50), adenoid cystic carcinoma(n=50), and pleomorphic adenoma(n=50).
Clinical data (age, sex, previous diseases ), physical examination, and investigations are done for all
patients. In addition. These 150 cases of paraffin embedding blocks of salivary tissue were stained by
ordinary stained (hematoxylin and eosin staining ). Manual IHC staining of GATA 3 was done. Results:
Age groups is younger for normal salivary gland tissues than PA, and ACC . Sex distribution was slightly
increase in male in comparison to female in normal salivary gland tissues and PA. GATA 3 staining was
showing more positivity in normal salivary gland tissues (43/50 patients) than PA (27/50 patients) and ACC
(14/50 patients). This positivity in GATA 3 IHC staining were more in male sex, regarding 55.8% in normal
salivary gland tissues than ACC 50% and PA 51.9% . Age group 31-40, 40-50 and 61-70 years were
showing more positive GATA 3 IHC staining in normal salivary gland tissues, PA, and ACC respectively.
there was insignificant association between GATA 3 IHC staining with either age groups or sex groups
distribution . Conclusion: GATA3 IHC is good marker and can used for searching salivary gland tumor
origin, assisting in diagnosis Salivary gland tumors subtypes but GATA3 IHC staining has no association
to specific sex or age groups in Salivary gland tumors. Usage of surgical operations for histopathological
specimens preparation are better and give good efficiency for IHC markers staining.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions