The Effect of Golden Sea Cucumber (StichopusHermanii) Extract on the Healing Process of the White Rat (Rattus Norvegicus) Indicated by Oral Ulcer– A Literature Review
Keywords:: Golden sea cucumber, (Stichopushermanii), Glycosaminoglycans, hyaluronic acid, heparan sulfate, chondroitin sulfate, keratin sulfate, fibroblasts, Oral ulcers
Background Indonesia is a maritime country that is rich in marine resources. There are many marine
resources that can be used as herbal medicine. One of them is the golden sea cucumber which is thought to
be used as an alternative medicine to speed up the healing process of oral ulcers. The purpose of this study
was to determine the effect of golden sea cucumber extract (Stichopushermanii) on the wound healing
process in rats with oral ulcers.
Method This research is a descriptive study with a literature review design. The articles used are articles
published in international and national journals in the 2015-2020 period and are indexed by Scopus, Thomson
Reuters, Web Science, Scimago and Sinta.
Result The results of the scoping article show that there are active compounds in golden sea cucumbers,
namely glycosaminoglycans that consist of hyaluronic acid, heparin / heparan sulfate (HP / HS), chondroitin
sulfate / dermatan sulfate (CS / DS) and keratin sulfate (KS) which can form proinflammatory cytokines to
trigger the emergence of immune defense cells and can bind to growth factors such as FGF2, VEGF, TGF-b,
which will provide stimulation to accelerate the angiogenesis process, fibroblast ploriferation, endothelial
differentiation, epithelial differentiation so as to accelerate the wound healing process.
ConclutionThe conclusion of this study is the golden sea cucumber has the potency to accelerate the wound
healing process by increasing fibroblast formation, collagen synthesis, endothelial differentiation and
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