The Role of Aloe vera and Centella asiatica to the Improvement of Skin Barrier Function in Indonesian Batik Workers

Abstract

Background: The batik industry uses dyes and candles, that can disrupt the skin barrier function and may
precipitate skin disease.
Objective: To determine the role of Aloe vera and Centella asiatica to the improvement of the skin barrier
function in Indonesian batik workers
Methods: This was a double blind clinical trial of 30 Indonesian batik workers were divided into 2 group
and given Aloe vera or Centella asiatica topical randomly was applied twice a day. Transepidermal water
loss (TEWL) level, stratum corneum hydration level, and pH level, were examined using Cutometer dual
MP-580.
Result: Sensitivity (Sn) of new local compared with imported allergen extracts in this study was between
15.38%-84.61%, the highest point was house dust mite extract. Specificity (Sp) was ranged from 81.48%-
93.75%, the highest rank was shrimp extract. Compared with IgE results, the Sn of new local and imported
house dust mite extracts was good (85.7%; 92.9%). The Sp was good for egg white and cow’s milk new local
extracts (86.4%; 84.4%).
Conclusion: Aloe vera topical gave significant improvement on palm area of TEWL level (P=0.033; CI
95%), stratum corneum hydration (P=0.000; CI 95%), and pH level (P=0.004; CI 95%); while on dorsal
hand area of stratum corneum hydration (P=0.002; CI 95%). Centella asiatica topical gave significant
improvement on palm area of stratum corneum hydration (P=0.007; CI 95%); while on dorsal hand area of
stratum corneum hydration (P=0.001; CI 95%) and pH level (P=0.17; CI 95%). No significant differences
of Aloe vera compared to Centella asiatica in the improvement of skin barrier function.