Drug Patch Test as a Diagnostic Test to Determine the Culprit Drug of Cutaneous Adverse Drug Reaction (CADR)

Authors

  • Damayanti
  • Hari Sukanto
  • Marsudi Hutomo
  • Sylvia Anggraeni
  • Menul Ayu Umborowati
  • Cita Rosita Sigit Prakoeswa

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15739

Keywords:

CADR, drug patch test, clinical relevance

Abstract

Background: Cutaneous Adverse Drug Reaction (CADR) is a frequent problem in clinical practice since
there were new drugs or drug misuse, which leads to high morbidity and mortality rate. It is often difficult to
determine the offending drug only from the history. Provocation test, intradermal test or skin prick test are
of significant value, but having higher risk to re-precipitate life-threatening reaction. Drug patch test (DPT)
is a test, which is performed to CADR patient to determine the culprit drug. The main advantages of DPT
are, it gives rarely adverse reaction and any commercialized form of drugs can be used.
Methods: This is a retrospective study, aimed to analize the clinical relevance between anamnesis and DPT
result in patient with history of CADR. All patient, who were performed with DPT in one year period in Dr.
Soetomo General Academic Hospital Surabaya Indonesia, were evaluated in this study.
Results: There were 14 patients with history of CADR, who performed DPT; consist of 7 maculopapular
eruption cases, 4 Stevens-Johnson Syndrome (SJS) cases, 1 Fixed Drug Eruption (FDE) case, 1 Acute
Generalized Exanthematous Pustulosis (AGEP) case and 1 Drug Reaction with Eosinophilia and Systemic
Reaction (DRESS) case. There were 9 patients (64.3 %), who got positive result of DPT. The relevance
between anamnesis and positive result of DPT were shown in 8 patient (88.9%) of 9 patient with positive
DPT result.
Conclusion: DPT has important role in identifying the culprit drug in CADR, especially when multiple
drugs are involved.

Author Biographies

Damayanti

Researcher, Department of Dermatology and Venereology, Faculty of Medicine Universitas Airlangga/
Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Hari Sukanto

Professor, Department of Dermatology and Venereology, Faculty of Medicine Universitas Airlangga/
Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Marsudi Hutomo

Researcher,Department of Dermatology and Venereology, Faculty of Medicine Universitas Airlangga/
Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Sylvia Anggraeni

Researcher, Department of Dermatology and Venereology, Faculty of Medicine Universitas Airlangga/
Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Menul Ayu Umborowati

Researcher, Department of Dermatology and Venereology, Faculty of Medicine Universitas Airlangga/
Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Cita Rosita Sigit Prakoeswa

Professor, Department of Dermatology and Venereology, Faculty of Medicine Universitas Airlangga/
Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Published

2021-05-17

How to Cite

Damayanti, Hari Sukanto, Marsudi Hutomo, Sylvia Anggraeni, Menul Ayu Umborowati, & Cita Rosita Sigit Prakoeswa. (2021). Drug Patch Test as a Diagnostic Test to Determine the Culprit Drug of Cutaneous Adverse Drug Reaction (CADR). Indian Journal of Forensic Medicine & Toxicology, 15(3), 2861-2866. https://doi.org/10.37506/ijfmt.v15i3.15739

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