Analysis of the Characteristics of SARS-Cov-2 Spike Compared to SARS-Cov Spike and Its Role in the Pathogenesis of Infection– A Literature Review

Authors

  • Galih Kathleyana
  • Sihning E.J.T
  • Diah Purwaningsar
  • Retno Budiarti

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15753

Keywords:

SARS-CoV-2, SARS-CoV, COVID-19 infection, coronavirus spike

Abstract

The spread of COVID-19 that caused by SARS-CoV-2 happened very fast & has infected many people. WHO
reported 1,051,635 cases of COVID-19 and 56,985 confirmed deaths caused by COVID-19 as of April 4,
2020. SARS-CoV-2 is a novel coronavirus that originates from betacoronavirus together with SARS-CoV.
This study aims to find and understand the differences between the SARS-CoV-2 and SARS-CoV spikes in
the infection and the spread of the resulting disease. This is a literature studies obtained from national journal
articles indexed by SINTA and international journals indexed by Scimago or Scopus and published in 2015-
2020. We concluded that there is a difference between the SARS-CoV-2 spike and the SARS-CoV spike, so
that it can affect the spread of the disease. SARS-CoV-2 has a furin cleavage site that absent in SARS-CoV.
The existence of this furin cleavage site can help the activation and the efficiency of the infection of the
SARS-CoV-2 and increases its transmissibility to organs and populations when compared to viruses without
furin cleavage sites such as SARS-CoV.

Author Biographies

Galih Kathleyana


Student,  Medicine, Hang Tuah University, Surabaya, Indonesia

Sihning E.J.T

Lecturers at Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia

Diah Purwaningsar

Lecturers at Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia

Retno Budiarti

Lecturers at Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia

Published

2021-05-17

How to Cite

Galih Kathleyana, Sihning E.J.T, Diah Purwaningsar, & Retno Budiarti. (2021). Analysis of the Characteristics of SARS-Cov-2 Spike Compared to SARS-Cov Spike and Its Role in the Pathogenesis of Infection– A Literature Review. Indian Journal of Forensic Medicine & Toxicology, 15(3), 2958-2963. https://doi.org/10.37506/ijfmt.v15i3.15753