Effectiveness of (Ki-67) a Cell Proliferative Marker for Distinguishing Overlapping Skin Lesions

Authors

  • Hala N. Al Salman
  • Qasim S. Al Chalabi
  • Anfal L. Al Harbawi

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15768

Keywords:

Basal cell carcinoma; Squamous cell carcinoma; Tricoepithelioma; Keratoacanthoma; Ki-67; Immunohistochemical staining.

Abstract

Background: it has been always a challenge to differentiate keratoacanthoma (KA) from squamous cell
carcinoma (SCC) and trichoepithelioma (TE) from Basal Cell Carcinoma (BCC). K-i67, a nuclear marker, is
a protein whose expression is strictly related to cell proliferation. Therefore, this can be used as an excellent
proliferative marker to differentiate between benign and malignant skin lesions.
Aim of the Current Study: this study was conducted to investigate the quantitative differences in nuclear
expression of the proliferative index (Ki-67) in SCC, KA, BCC and TE.
Materials and Methods: A cross-sectional study enrolling 65 patients selected from private dermatological
outpatients clinics at Ibn-Sina Teaching Hospital, Mosul, Iraq diagnosed clinically by dermatologists as
BCC, SCC, KA, and TE during the period from Jan 2019- Jan 2020. Their biopsies were sent for routine
histopathological study and additional Immunohistochemical staining using a Ki-67 marker.
Results: Ki- 67 expression was seen in all cases ranging in intensity between 3-70%. Moderate expression
was noticed in (79%) of BCC cases whereas (43%) of well-differentiated SCC cases had mild expression.
Quite the reverse, the intensity of Ki-67 immunostaining ranged from 1-20% and 1-5% in KA and TE
respectively.
Conclusion: Ki-67 can be used as a significant biological marker to differentiate between benignity and
malignancy of overlapping

Author Biographies

Hala N. Al Salman

Lecturer in Mosul University/Department of Medicine/Dermatology Section

Qasim S. Al Chalabi

Lecturer in Mosul University/Department of Medicine/Dermatology Section

Anfal L. Al Harbawi

Lecturer in Mosul University/Department of Medicine/Dermatology Section

Published

2021-05-17

How to Cite

Salman, H. N. A. ., Chalabi, Q. S. A. ., & Harbawi, A. L. A. . (2021). Effectiveness of (Ki-67) a Cell Proliferative Marker for Distinguishing Overlapping Skin Lesions. Indian Journal of Forensic Medicine & Toxicology, 15(3), 3059-3066. https://doi.org/10.37506/ijfmt.v15i3.15768

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