Effectiveness of (Ki-67) a Cell Proliferative Marker for Distinguishing Overlapping Skin Lesions
Keywords:Basal cell carcinoma; Squamous cell carcinoma; Tricoepithelioma; Keratoacanthoma; Ki-67; Immunohistochemical staining.
Background: it has been always a challenge to differentiate keratoacanthoma (KA) from squamous cell
carcinoma (SCC) and trichoepithelioma (TE) from Basal Cell Carcinoma (BCC). K-i67, a nuclear marker, is
a protein whose expression is strictly related to cell proliferation. Therefore, this can be used as an excellent
proliferative marker to differentiate between benign and malignant skin lesions.
Aim of the Current Study: this study was conducted to investigate the quantitative differences in nuclear
expression of the proliferative index (Ki-67) in SCC, KA, BCC and TE.
Materials and Methods: A cross-sectional study enrolling 65 patients selected from private dermatological
outpatients clinics at Ibn-Sina Teaching Hospital, Mosul, Iraq diagnosed clinically by dermatologists as
BCC, SCC, KA, and TE during the period from Jan 2019- Jan 2020. Their biopsies were sent for routine
histopathological study and additional Immunohistochemical staining using a Ki-67 marker.
Results: Ki- 67 expression was seen in all cases ranging in intensity between 3-70%. Moderate expression
was noticed in (79%) of BCC cases whereas (43%) of well-differentiated SCC cases had mild expression.
Quite the reverse, the intensity of Ki-67 immunostaining ranged from 1-20% and 1-5% in KA and TE
Conclusion: Ki-67 can be used as a significant biological marker to differentiate between benignity and
malignancy of overlapping
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