The Effect of Brown Seaweed (Sargassum sp.) Extract on Apoptosis Process in Breast Cancer – A Literature Review

Authors

  • Ismylatifa Devi
  • Diah Purwaningsari
  • Nita Pranitasari
  • HerinSetianingsih

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15803

Keywords:

Apoptosis, Breast Cancer, Brown Seaweed,Oxidative Stress, Proapoptotic, Sargassumsp..

Abstract

Breast cancer was one of the most common types of cancer in women and the major cause of death.
Chemotherapy in breast cancer caused toxicity to the normal cells, resistance to the drugs, and several other
side effects. Seaweed had many functional compounds that could be used as adjuvant therapy in breast
cancer because of its anti-cancer properties called the proapoptotic agent. These compounds were fucoidan,
phloroglucinol, and fucoxanthin. Their proapoptotic mechanisms shown by the journal were through
increasing proapoptotic protein expression, decreasing antiapoptotic protein expression, inducing oxidative
stress production on the cancer cell, and inhibiting the PI3K pathway. This review concludes that the brown
seaweed (Sargassum sp.), which contains fucoidan, phloroglucinol, and fucoxanthin, could increase breast
cancer cells’ apoptotic process.

Author Biographies

Ismylatifa Devi

Studentat Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia

Diah Purwaningsari

Lecturers at Faculty of Medicine,
Hang Tuah University, Surabaya, Indonesia

Nita Pranitasari

Lecturers at Faculty of Medicine,
Hang Tuah University, Surabaya, Indonesia

HerinSetianingsih

Lecturers at Faculty of Medicine,
Hang Tuah University, Surabaya, Indonesia

Published

2021-05-17

How to Cite

Ismylatifa Devi, Diah Purwaningsari, Nita Pranitasari, & HerinSetianingsih. (2021). The Effect of Brown Seaweed (Sargassum sp.) Extract on Apoptosis Process in Breast Cancer – A Literature Review. Indian Journal of Forensic Medicine & Toxicology, 15(3), 3247-3251. https://doi.org/10.37506/ijfmt.v15i3.15803