Detrimental Effect of Alprazolam on Sperm Viability ofMice (Mus musculus) Exposed to Chronic Unpredictable Mild Stress

Authors

  • Intan Indah Permatasari
  • Reny I’tishom
  • HanikBadriyah Hidayati
  • Irwanto

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15805

Keywords:

Chronic Unpredictable Mild Stress, Alprazolam, Viability, Sperm

Abstract

Objective: This study aims to investigate the effect of alprazolam administration on sperm viability of mice
(Mus musculus) strain Balb/C following CUMSfor 53 days. Method: This study used a true experimental
design through randomization. Control group kept undisturbed without treatment and therapy throughout 60
days. K1 and K2 were exposed to a 53 day period of CUMS along with 7-day pretreatment adaptation. K2
was adapted for a week, stressed for 53 days along with cotreatment of alprazolam (4 mg/kg BW). Results:
K1 and K2 showed insignificant improvement of sperm viability (p > 0.05).Meanwhile, K0 and K1 showed
significant value compared to K2 (p<0.05). K2 showed little increase of sperm viability in CUMS group
along with subsequent treatment of alprazolam. Conclusion: Overall, the results indicate an insignificant
effect of alprazolam on sperm viability of CUMS-induced mice.

Author Biographies

Intan Indah Permatasari


Researcher, Faculty of Medicine, Universitas Airlangga,Surabaya,Indonesia

Reny I’tishom

Associate Professor, Department of
Medical Biology,Faculty of Medicine,Universitas Airlangga, Surabaya, Indonesia

HanikBadriyah Hidayati


Associate Professor,Department
of Neurology, Faculty of Medicine, Universitas Airlangga, Surabaya,Indonesia

Irwanto

Professor, Department of Child
Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Published

2021-05-17

How to Cite

Intan Indah Permatasari, Reny I’tishom, HanikBadriyah Hidayati, & Irwanto. (2021). Detrimental Effect of Alprazolam on Sperm Viability ofMice (Mus musculus) Exposed to Chronic Unpredictable Mild Stress. Indian Journal of Forensic Medicine & Toxicology, 15(3), 3259-2365. https://doi.org/10.37506/ijfmt.v15i3.15805