Risk Factor of Preeclampsia in a Secondary Indonesian Hospital: A Case-Control Study
Keywords:Risk factor, Preeclampsia, Hypertension in pregnancy
Background: Preeclampsia is a form of hypertension in pregnancy that leads to morbidity and mortality.
Although the etiology remains unclear, there are some risk factors that are suspected to be associated with
the development ofpreeclampsia. Objective: To find out the risk factors associated with the incidence of
preeclampsia inAirlangga University Hospital. Method: This studyconducted an analytical-observational
study with the hospitalized unmatchedbased case-control approach. 165 pregnant women were included.
Data were analyzed in univariate, bivariate, and multivariate regression logistic and performed using
statistical package for the social science (SPSS), p < 0.05 was considered statistically significant. Results:
Pregnant women with preeclampsia were about 18 to 44 years old, with the average BMIis 31.19 kg/m2.
There are significant relation between family history of hypertension (p = 0.000), maternal age (p = 0.004),
BMI (p = 0.000), pregnancy interval (p = 0.009), and chronic hypertension (p = 0.007) with the incidence
of preeclampsia. In the multivariate analysis using logistic regression, family history of hypertension was
the most dominant factor with OR: 3.374 and 95% CI: 1.454 – 7.830 compared to other factors such as
maternal age (OR: 2.885; 95% CI: 1.311 – 6.347; p: 0.008) , and BMI (OR: 2.590; 95% CI: 1.525 – 4.400;
p: 0.000). Conclusion: Family history of hypertension, maternal age, BMI, pregnancy interval, and chronic
hypertension have a significant relationship with the incidence of preeclampsia. In multivariate analysis,
family history of hypertension is the most dominant risk factor among others.
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