The Genetic Aspect of Non-Syndromic Cleft Lip and Palate towards Candidate Genes in the Etiology : A literature Review

Authors

  • Mala Kurniati
  • RM Coen Pramono D
  • Agung Sosiawan
  • Ni Wayan Tirtaningsih

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15859

Keywords:

: Cleft Lip, Cleft Palate, Genetic

Abstract

Cleft lip and cleft palate (CL/P) is a cleft lip deformity indicated by an opening or an uncommon cleft in
the lip or roof of the mouth (palate). The differences in ethnicity, gender, and the correlation with genetic
factors influence the prevalence of Non-syndromic CL/P. This study was conducted through a literature
review on genes that were allegedly associated with Non-syndromic CL/P. Genetics play a role, to a greater
or lesser extent, in all diseases. Besides, palatogenesis involves many diverse genes in a complex process.
In this case, oral cleft phenotypes develop when this process is disrupted in some manner because of gene
dysfunction. Various genetic approaches, including genome-wide and candidate gene association studies
as well as linkage analysis, have been undertaken to identify etiologic factors, but results have often been
inconclusive or contradictory. Therefore, it concludes that the genetic basis of CL/P is still controversial
because of the genetic complexity of clefting.

Author Biographies

Mala Kurniati

Post Graduate Doctoral Program, Faculty of Medicine, Universitas Airlangga, Surabaya-Indonesia

RM Coen Pramono D

Lecterur,
Department of Biology, Faculty of Medicine, Universitas Malahayati, Lampung, Indonesia

Agung Sosiawan

Senior
Lecterur, Department of Dental Public Health, Faculty of Dental Medicine, Universitas Airlangga, Surabaya,
Indonesia

Ni Wayan Tirtaningsih

Senior Lecterur, Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga,
Surabaya, Indonesia

Published

2021-05-17

How to Cite

Mala Kurniati, RM Coen Pramono D, Agung Sosiawan, & Ni Wayan Tirtaningsih. (2021). The Genetic Aspect of Non-Syndromic Cleft Lip and Palate towards Candidate Genes in the Etiology : A literature Review. Indian Journal of Forensic Medicine & Toxicology, 15(3), 3604-3608. https://doi.org/10.37506/ijfmt.v15i3.15859