Exercise Intensity May affect Bdnf Level in the Hippocampus of Fructose-Induced Mice

Abstract

Introduction – Several studies show that there is a negative correlation between obesity and cognitive
function. Exercise can reverse the bad effect of obesity through mediation of BDNF. Research about the
effect of exercise intensity to BNDF levels in hippocampus of mice is ever be done, but research about the
effect of exercise intensity to BNDF levels in hippocampus of fructose-induced mice is never be done.
Objective – To prove the effect of different exercise intensity to BDNF level in hippocampus of fructoseinduced mice.
Methods – A total of 32 mice were divided into four groups: Control group which was a CON and treatment
groups which were low-intensity exercise (LIE), moderate-intensity exercise (MIE), and high-intensity
exercise (HIE). The duration of treatment was 4 weeks. Swimming to exercise held 3 times a week and
fructose solution dose was 270 grams for 9 days.
Results – This research revealed that there was significantly difference on body weight before and after
administration of fructose solution for 9 days (p=0.000). The lowest BDNF levels after treatment was group
C and the highest of BDNF levels was group MI. There was no significantly difference in BDNF levels
among groups after treatment (p=0.378), but there was tendency for BDNF levels to increase with exercise
intensity.
Conclusion – Swimming exercise with low-intensity, moderate-intensity, and high intensity has no effect on
BDNF level in the hippocampus of fructose-induced mice.