The Anti-Inflammatory Effect of ACE-I/ARBs Drug on hs-CRP and HDL-Cholesterol in CKD Patient

Authors

  • Muhammad Iqbal Mubarok
  • Maftuchah Rochmanti
  • Mochamad Yusuf
  • Mochammad Thaha

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15878

Keywords:

Chronic kidney disease, ACE-I, ARBs, hs-CRP, HDL Cholesterol

Abstract

Chronic kidney disease (CKD) is progressive disease that closely related to the chronic inflammatory process.
Angiotensin-Converting Enzyme Inhibitor (ACE-I)/Angiotensin Receptor Blockers (ARBs) is the main
therapy in the management of CKD, based on the recent sudies stated that this drug have pleiotropic effects
as anti-inflammation.The aim of this study is tosee the interaction of hs-CRP and HDL-Cholesterol to prove
the role of ACE-I/ARBs as an anti-inflammatory treatment for CKD patient. In this study we compared hsCRP, HDL Cholesterol and HDL Cholesterol /hs-CRP ratio levels in CKD patients who consumeand do not
consumeACE-I/ARBs. Forty eight samples of CKD patients were taken randomly and then separated into
two group based on their consumption of ACE-I/ARBs, each group have 24 samples.There were significantly
different of mean of hs-CRP, HDL Cholesterol, and HDL Cholesterol/hs-CRP ratio between group, the mean
concentration of hs-CRP in the ACE-I/ARBs group was significantly lower than in non-ACE-I/ARBs group
(1,48±0,81 vs 4,19±4,02; P= 0.038),the mean of HDL (48,95±13,05vs 41,50±12,31; P= 0,048).There were
negative correlation between HDL Cholesterol and hs-CRP, positive correlation between HDL Cholesterol/
hs-CRP ratio and eGFR.This result indicate that hs-CRP and HDL-Cholesterol monitoring very important
in CKD patient.

Author Biographies

Muhammad Iqbal Mubarok

Student, Faculty of Medicine, UniversitasAirlangga, Surabaya, Indonesia

Maftuchah Rochmanti

Lecturer, Department of
Pharmacology, Faculty of Medicine, UniversitasAirlangga, Surabaya, Indonesia,

Mochamad Yusuf

Lecturer, Department of
Cardiology and Vascular Medicine, Faculty of Medicine, UniversitasAirlangga, Surabaya, Indonesia

Mochammad Thaha

Lecturer,
Department of Internal Medicine, Faculty of Medicine, UniversitasAirlangga, Surabaya, Indonesia

Published

2021-05-17

How to Cite

Muhammad Iqbal Mubarok, Maftuchah Rochmanti, Mochamad Yusuf, & Mochammad Thaha. (2021). The Anti-Inflammatory Effect of ACE-I/ARBs Drug on hs-CRP and HDL-Cholesterol in CKD Patient. Indian Journal of Forensic Medicine & Toxicology, 15(3), 3743-3750. https://doi.org/10.37506/ijfmt.v15i3.15878

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